Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes
Abstract Background LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid atherosclerotic plaques in patients with LADA as compared wi...
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-017-0576-9 |
| _version_ | 1811263518798774272 |
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| author | Marta Hernández Carolina López Jordi Real Joan Valls Emilio Ortega-Martinez de Victoria Federico Vázquez Esther Rubinat Minerva Granado-Casas Nuria Alonso Teresa Molí Angels Betriu Albert Lecube Elvira Fernández Richard David Leslie Dídac Mauricio |
| author_facet | Marta Hernández Carolina López Jordi Real Joan Valls Emilio Ortega-Martinez de Victoria Federico Vázquez Esther Rubinat Minerva Granado-Casas Nuria Alonso Teresa Molí Angels Betriu Albert Lecube Elvira Fernández Richard David Leslie Dídac Mauricio |
| author_sort | Marta Hernández |
| collection | DOAJ |
| description | Abstract Background LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid atherosclerotic plaques in patients with LADA as compared with patients with classic type 1 diabetes and type 2 diabetes. Methods Patients with LADA were matched for age and gender in different proportions to patients with type 2 diabetes, and classic type 1 diabetes. None of the patients had clinical cardiovascular disease. All subjects underwent B-mode carotid ultrasound to detect atheroma plaques. Demographics were obtained from all subjects. Results We included 71 patients with LADA, 191 patients with type 2 diabetes and 116 patients with type 1 diabetes. Carotid atherosclerosis was more frequent in patients with LADA compared with type 2 diabetes (73.2% vs. 56.9%, P = 0.0018) and classic type 1 diabetes (57.1%, P = 0.026); these changes occurred despite healthier macrovascular risk profiles in the former. Age (P < 0.001), smoking (P = 0.003) and hypertension (P = 0.019) were independently associated with carotid atherosclerosis. Multiple plaques were also more frequent in patients with LADA as compared with classic type 1 diabetes and type 2 diabetes (45.1% and 33.6% vs. 27.2%, respectively, P = 0.022). The frequency of carotid plaques increased with increasing diabetes duration in LADA patients compared with type 2 diabetes (85.7% vs. 58.8%, inverse OR 5.72 [1.5–21.8]; P = 0.009). Conclusions LADA patients do not present with less carotid atherosclerosis than patients with type 1 and type 2 diabetes. Their macrovascular risk occurs despite a healthier macrovascular risk profile than those patients with type 2 diabetes. |
| first_indexed | 2024-04-12T19:46:51Z |
| format | Article |
| id | doaj.art-bc51f99d83184a5a86cd21aef625c353 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-12T19:46:51Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-bc51f99d83184a5a86cd21aef625c3532022-12-22T03:18:57ZengBMCCardiovascular Diabetology1475-28402017-07-011611910.1186/s12933-017-0576-9Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetesMarta Hernández0Carolina López1Jordi Real2Joan Valls3Emilio Ortega-Martinez de Victoria4Federico Vázquez5Esther Rubinat6Minerva Granado-Casas7Nuria Alonso8Teresa Molí9Angels Betriu10Albert Lecube11Elvira Fernández12Richard David Leslie13Dídac Mauricio14Department of Endocrinology and Nutrition, University Hospital Arnau de VilanovaNursing School, Universitat de LleidaUnitat de Suport a la Recerca Lleida, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol)Institut de Recerca Biomèdica de LleidaDepartment of Endocrinology and Nutrition, CIBEROBN-Spanish Biomedical Research Centre in Physiopathology of Obesity, Hospital ClínicDepartment of Endocrinology and Nutrition, CIBER of Diabetes and Associated Metabolic Diseases, Health Sciences Research Institute & University Hospital Germans Trias i PujolNursing School, Universitat de LleidaNursing School, Universitat de LleidaDepartment of Endocrinology and Nutrition, CIBER of Diabetes and Associated Metabolic Diseases, Health Sciences Research Institute & University Hospital Germans Trias i PujolUDETMA, Department of Nephrology, University Hospital Arnau de VilanovaInstitut de Recerca Biomèdica de LleidaDepartment of Endocrinology and Nutrition, University Hospital Arnau de VilanovaUDETMA, Department of Nephrology, University Hospital Arnau de VilanovaThe Blizard Institute, Barts and the London School of Medicine and DentistryInstitut de Recerca Biomèdica de LleidaAbstract Background LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid atherosclerotic plaques in patients with LADA as compared with patients with classic type 1 diabetes and type 2 diabetes. Methods Patients with LADA were matched for age and gender in different proportions to patients with type 2 diabetes, and classic type 1 diabetes. None of the patients had clinical cardiovascular disease. All subjects underwent B-mode carotid ultrasound to detect atheroma plaques. Demographics were obtained from all subjects. Results We included 71 patients with LADA, 191 patients with type 2 diabetes and 116 patients with type 1 diabetes. Carotid atherosclerosis was more frequent in patients with LADA compared with type 2 diabetes (73.2% vs. 56.9%, P = 0.0018) and classic type 1 diabetes (57.1%, P = 0.026); these changes occurred despite healthier macrovascular risk profiles in the former. Age (P < 0.001), smoking (P = 0.003) and hypertension (P = 0.019) were independently associated with carotid atherosclerosis. Multiple plaques were also more frequent in patients with LADA as compared with classic type 1 diabetes and type 2 diabetes (45.1% and 33.6% vs. 27.2%, respectively, P = 0.022). The frequency of carotid plaques increased with increasing diabetes duration in LADA patients compared with type 2 diabetes (85.7% vs. 58.8%, inverse OR 5.72 [1.5–21.8]; P = 0.009). Conclusions LADA patients do not present with less carotid atherosclerosis than patients with type 1 and type 2 diabetes. Their macrovascular risk occurs despite a healthier macrovascular risk profile than those patients with type 2 diabetes.http://link.springer.com/article/10.1186/s12933-017-0576-9Carotid plaqueAtherosclerosisLate onset autoimmune diabetesLADAType 1 diabetesType 2 diabetes |
| spellingShingle | Marta Hernández Carolina López Jordi Real Joan Valls Emilio Ortega-Martinez de Victoria Federico Vázquez Esther Rubinat Minerva Granado-Casas Nuria Alonso Teresa Molí Angels Betriu Albert Lecube Elvira Fernández Richard David Leslie Dídac Mauricio Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes Cardiovascular Diabetology Carotid plaque Atherosclerosis Late onset autoimmune diabetes LADA Type 1 diabetes Type 2 diabetes |
| title | Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes |
| title_full | Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes |
| title_fullStr | Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes |
| title_full_unstemmed | Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes |
| title_short | Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes |
| title_sort | preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults lada type 2 diabetes and classical type 1 diabetes |
| topic | Carotid plaque Atherosclerosis Late onset autoimmune diabetes LADA Type 1 diabetes Type 2 diabetes |
| url | http://link.springer.com/article/10.1186/s12933-017-0576-9 |
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