White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression
More than one-third of depressive patients do not achieve remission after the first antidepressant treatment. The “watch and wait” approach used to find the most effective antidepressant leads to an increased personal, social, and economic burden in society. In order to overcome this challenge, ther...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.693109/full |
| _version_ | 1819071911537147904 |
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| author | Rita Vieira Rita Vieira Rita Vieira Ana Coelho Ana Coelho Ana Coelho Joana Reis Joana Reis Joana Reis Carlos Portugal-Nunes Carlos Portugal-Nunes Carlos Portugal-Nunes Ricardo Magalhães Ricardo Magalhães Ricardo Magalhães Ricardo Magalhães Sónia Ferreira Sónia Ferreira Sónia Ferreira Pedro Silva Moreira Pedro Silva Moreira Pedro Silva Moreira Pedro Silva Moreira Nuno Sousa Nuno Sousa Nuno Sousa João M. Bessa João M. Bessa João M. Bessa |
| author_facet | Rita Vieira Rita Vieira Rita Vieira Ana Coelho Ana Coelho Ana Coelho Joana Reis Joana Reis Joana Reis Carlos Portugal-Nunes Carlos Portugal-Nunes Carlos Portugal-Nunes Ricardo Magalhães Ricardo Magalhães Ricardo Magalhães Ricardo Magalhães Sónia Ferreira Sónia Ferreira Sónia Ferreira Pedro Silva Moreira Pedro Silva Moreira Pedro Silva Moreira Pedro Silva Moreira Nuno Sousa Nuno Sousa Nuno Sousa João M. Bessa João M. Bessa João M. Bessa |
| author_sort | Rita Vieira |
| collection | DOAJ |
| description | More than one-third of depressive patients do not achieve remission after the first antidepressant treatment. The “watch and wait” approach used to find the most effective antidepressant leads to an increased personal, social, and economic burden in society. In order to overcome this challenge, there has been a focus on studying neural biomarkers associated with antidepressant response. Diffusion tensor imaging measures have shown a promising role as predictors of antidepressant response by pointing to pretreatment differences in the white matter microstructural integrity between future responders and non-responders to different pharmacotherapies. Therefore, the aim of the present study was to explore whether response to paroxetine treatment was associated with differences in the white matter microstructure at baseline. Twenty drug-naive patients diagnosed with major depressive disorder followed a 6- to 12-week treatment with paroxetine. All patients completed magnetic resonance brain imaging and a clinical assessment at baseline and 6–12 weeks after treatment. Whole-brain tract-based spatial statistics was used to explore differences in white matter microstructural properties estimated from diffusion magnetic resonance imaging. Voxel-wise statistical analysis revealed a significant increase in fractional anisotropy and a decrease in radial diffusivity in forceps minor and superior longitudinal fasciculus in responders compared to non-responders. Thus, alterations in white matter integrity, specifically in forceps minor and the superior longitudinal fasciculus, are associated with paroxetine treatment response. These findings pave the way for personalized treatment strategies in major depression. |
| first_indexed | 2024-12-21T17:29:21Z |
| format | Article |
| id | doaj.art-bc521491b20b4b01b13d7d3109b37a6f |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-21T17:29:21Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-bc521491b20b4b01b13d7d3109b37a6f2022-12-21T18:55:58ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532021-07-011510.3389/fnbeh.2021.693109693109White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major DepressionRita Vieira0Rita Vieira1Rita Vieira2Ana Coelho3Ana Coelho4Ana Coelho5Joana Reis6Joana Reis7Joana Reis8Carlos Portugal-Nunes9Carlos Portugal-Nunes10Carlos Portugal-Nunes11Ricardo Magalhães12Ricardo Magalhães13Ricardo Magalhães14Ricardo Magalhães15Sónia Ferreira16Sónia Ferreira17Sónia Ferreira18Pedro Silva Moreira19Pedro Silva Moreira20Pedro Silva Moreira21Pedro Silva Moreira22Nuno Sousa23Nuno Sousa24Nuno Sousa25João M. Bessa26João M. Bessa27João M. Bessa28Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, PortugalClinical Academic Center – Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, PortugalClinical Academic Center – Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, PortugalClinical Academic Center – Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, PortugalClinical Academic Center – Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, PortugalClinical Academic Center – Braga, Braga, PortugalNeuroSpin, Institut des Sciences du Vivant Frédéric Joliot, Commissariat à l’ Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, Gif-sur-Yvette, FranceLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, PortugalClinical Academic Center – Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, PortugalClinical Academic Center – Braga, Braga, PortugalPsychological Neuroscience Laboratory, CIPsi, School of Psychology, University of Minho, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, PortugalClinical Academic Center – Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, PortugalClinical Academic Center – Braga, Braga, PortugalMore than one-third of depressive patients do not achieve remission after the first antidepressant treatment. The “watch and wait” approach used to find the most effective antidepressant leads to an increased personal, social, and economic burden in society. In order to overcome this challenge, there has been a focus on studying neural biomarkers associated with antidepressant response. Diffusion tensor imaging measures have shown a promising role as predictors of antidepressant response by pointing to pretreatment differences in the white matter microstructural integrity between future responders and non-responders to different pharmacotherapies. Therefore, the aim of the present study was to explore whether response to paroxetine treatment was associated with differences in the white matter microstructure at baseline. Twenty drug-naive patients diagnosed with major depressive disorder followed a 6- to 12-week treatment with paroxetine. All patients completed magnetic resonance brain imaging and a clinical assessment at baseline and 6–12 weeks after treatment. Whole-brain tract-based spatial statistics was used to explore differences in white matter microstructural properties estimated from diffusion magnetic resonance imaging. Voxel-wise statistical analysis revealed a significant increase in fractional anisotropy and a decrease in radial diffusivity in forceps minor and superior longitudinal fasciculus in responders compared to non-responders. Thus, alterations in white matter integrity, specifically in forceps minor and the superior longitudinal fasciculus, are associated with paroxetine treatment response. These findings pave the way for personalized treatment strategies in major depression.https://www.frontiersin.org/articles/10.3389/fnbeh.2021.693109/fulldepressionparoxetineSSRItreatment responsediffusion MRIwhite-matter |
| spellingShingle | Rita Vieira Rita Vieira Rita Vieira Ana Coelho Ana Coelho Ana Coelho Joana Reis Joana Reis Joana Reis Carlos Portugal-Nunes Carlos Portugal-Nunes Carlos Portugal-Nunes Ricardo Magalhães Ricardo Magalhães Ricardo Magalhães Ricardo Magalhães Sónia Ferreira Sónia Ferreira Sónia Ferreira Pedro Silva Moreira Pedro Silva Moreira Pedro Silva Moreira Pedro Silva Moreira Nuno Sousa Nuno Sousa Nuno Sousa João M. Bessa João M. Bessa João M. Bessa White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression Frontiers in Behavioral Neuroscience depression paroxetine SSRI treatment response diffusion MRI white-matter |
| title | White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression |
| title_full | White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression |
| title_fullStr | White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression |
| title_full_unstemmed | White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression |
| title_short | White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression |
| title_sort | white matter microstructure alterations associated with paroxetine treatment response in major depression |
| topic | depression paroxetine SSRI treatment response diffusion MRI white-matter |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.693109/full |
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