Serum zinc concentration in patients with myocardial infarction: a retrospective study
Abstract Background Zinc regulates the oxidative stress and inflammatory signaling cascade and affects the development and deterioration of cardiovascular disease. We investigated the prognosis of developing heart failure in patients with myocardial infarction. Methods Patients with myocardial infar...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-024-03776-4 |
| _version_ | 1797276013352189952 |
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| author | Atsushi Tanita Shigeto Namiuchi Kenta Onodera Shinichiro Sunamura Tsuyoshi Ogata Kazuki Noda Toru Takii |
| author_facet | Atsushi Tanita Shigeto Namiuchi Kenta Onodera Shinichiro Sunamura Tsuyoshi Ogata Kazuki Noda Toru Takii |
| author_sort | Atsushi Tanita |
| collection | DOAJ |
| description | Abstract Background Zinc regulates the oxidative stress and inflammatory signaling cascade and affects the development and deterioration of cardiovascular disease. We investigated the prognosis of developing heart failure in patients with myocardial infarction. Methods Patients with myocardial infarction (n = 243) were divided using the median value of zinc concentration on admission into low (< 66 µg/dL at admission, n = 111) and high zinc group (≥ 66 µg/dL at admission, n = 132). During follow-up (mean ± SD: 734 ± 597 days; median 691 days), admission due to heart failure was observed in 12 patients: 10 and 2 cases in the low and high zinc groups, respectively. Results The risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.0043). Relative to the high zinc group, the hazard ratio for admission due to heart failure was 15.7 (95% confidence interval 1.11–221, P = 0.042) via adjusted Cox proportional hazards analysis. Even after propensity score matching, the risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.048). Conclusion Low serum zinc concentration may be a risk factor for admission due to heart failure after myocardial infarction. |
| first_indexed | 2024-03-07T15:21:14Z |
| format | Article |
| id | doaj.art-bc53e9a2b30543b788a08a115d6e8b97 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-07T15:21:14Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-bc53e9a2b30543b788a08a115d6e8b972024-03-05T17:37:50ZengBMCBMC Cardiovascular Disorders1471-22612024-02-012411710.1186/s12872-024-03776-4Serum zinc concentration in patients with myocardial infarction: a retrospective studyAtsushi Tanita0Shigeto Namiuchi1Kenta Onodera2Shinichiro Sunamura3Tsuyoshi Ogata4Kazuki Noda5Toru Takii6Department of Cardiology, Sendai City Medical Center, Sendai Open HospitalDepartment of Cardiology, Sendai City Medical Center, Sendai Open HospitalDepartment of Cardiology, Sendai City Medical Center, Sendai Open HospitalDepartment of Cardiology, Sendai City Medical Center, Sendai Open HospitalDepartment of Cardiology, Sendai City Medical Center, Sendai Open HospitalDepartment of Cardiology, Sendai City Medical Center, Sendai Open HospitalDepartment of Cardiology, Sendai City Medical Center, Sendai Open HospitalAbstract Background Zinc regulates the oxidative stress and inflammatory signaling cascade and affects the development and deterioration of cardiovascular disease. We investigated the prognosis of developing heart failure in patients with myocardial infarction. Methods Patients with myocardial infarction (n = 243) were divided using the median value of zinc concentration on admission into low (< 66 µg/dL at admission, n = 111) and high zinc group (≥ 66 µg/dL at admission, n = 132). During follow-up (mean ± SD: 734 ± 597 days; median 691 days), admission due to heart failure was observed in 12 patients: 10 and 2 cases in the low and high zinc groups, respectively. Results The risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.0043). Relative to the high zinc group, the hazard ratio for admission due to heart failure was 15.7 (95% confidence interval 1.11–221, P = 0.042) via adjusted Cox proportional hazards analysis. Even after propensity score matching, the risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.048). Conclusion Low serum zinc concentration may be a risk factor for admission due to heart failure after myocardial infarction.https://doi.org/10.1186/s12872-024-03776-4ZincHeart failureMyocardial infarctionOxidative stress |
| spellingShingle | Atsushi Tanita Shigeto Namiuchi Kenta Onodera Shinichiro Sunamura Tsuyoshi Ogata Kazuki Noda Toru Takii Serum zinc concentration in patients with myocardial infarction: a retrospective study BMC Cardiovascular Disorders Zinc Heart failure Myocardial infarction Oxidative stress |
| title | Serum zinc concentration in patients with myocardial infarction: a retrospective study |
| title_full | Serum zinc concentration in patients with myocardial infarction: a retrospective study |
| title_fullStr | Serum zinc concentration in patients with myocardial infarction: a retrospective study |
| title_full_unstemmed | Serum zinc concentration in patients with myocardial infarction: a retrospective study |
| title_short | Serum zinc concentration in patients with myocardial infarction: a retrospective study |
| title_sort | serum zinc concentration in patients with myocardial infarction a retrospective study |
| topic | Zinc Heart failure Myocardial infarction Oxidative stress |
| url | https://doi.org/10.1186/s12872-024-03776-4 |
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