Primary cardiac manifestation of autosomal dominant polycystic kidney disease revealed by patient induced pluripotent stem cell-derived cardiomyocytesResearch in context

Primary cardiac manifestation of autosomal dominant polycystic kidney disease revealed by patient induced pluripotent stem cell-derived cardiomyocytesResearch in context

Background: Mutations in PKD1 or PKD2 gene lead to autosomal dominant polycystic kidney disease (ADPKD). The mechanism of ADPKD progression and its link to increased cardiovascular mortality is still elusive. Methods: We differentiated ADPKD patient induced pluripotent stem cells (iPSCs) to cardiomy...

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Bibliographic Details
Main Authors: Jia-Jung Lee, Sin-Jhong Cheng, Ching-Ying Huang, Chen-Yun Chen, Li Feng, Daw-Yang Hwang, Timothy J. Kamp, Hung-Chun Chen, Patrick C.H. Hsieh
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419300118

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