Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives

Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. Its constituent protein β-tubulin has been a common drug target for various diseases including cancer. Colchicine has been used to treat gout, but it has also been an investigational anticance...

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Bibliographic Details
Main Authors: Urszula Majcher, Greta Klejborowska, Mahshad Moshari, Ewa Maj, Joanna Wietrzyk, Franz Bartl, Jack A. Tuszynski, Adam Huczyński
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cells
Subjects:
colchicine binding site inhibitor
β-tubulin affinity
antimitotic agent
antiproliferative activity
thiocolchicine
Online Access:https://www.mdpi.com/2073-4409/7/11/192

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