‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA
The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target. Sadly, unprecedented high rates of adverse events have overshadowed the benefits. This two-part narrative review presents eviden...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/8/2287 |
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| author | Peter I. Parry Astrid Lefringhausen Conny Turni Christopher J. Neil Robyn Cosford Nicholas J. Hudson Julian Gillespie |
| author_facet | Peter I. Parry Astrid Lefringhausen Conny Turni Christopher J. Neil Robyn Cosford Nicholas J. Hudson Julian Gillespie |
| author_sort | Peter I. Parry |
| collection | DOAJ |
| description | The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target. Sadly, unprecedented high rates of adverse events have overshadowed the benefits. This two-part narrative review presents evidence for the widespread harms of novel product COVID-19 mRNA and adenovectorDNA vaccines and is novel in attempting to provide a thorough overview of harms arising from the new technology in vaccines that relied on human cells producing a foreign antigen that has evidence of pathogenicity. This first paper explores peer-reviewed data counter to the ‘safe and effective’ narrative attached to these new technologies. Spike protein pathogenicity, termed ‘spikeopathy’, whether from the SARS-CoV-2 virus or produced by vaccine gene codes, akin to a ‘synthetic virus’, is increasingly understood in terms of molecular biology and pathophysiology. Pharmacokinetic transfection through body tissues distant from the injection site by lipid-nanoparticles or viral-vector carriers means that ‘spikeopathy’ can affect many organs. The inflammatory properties of the nanoparticles used to ferry mRNA; N1-methylpseudouridine employed to prolong synthetic mRNA function; the widespread biodistribution of the mRNA and DNA codes and translated spike proteins, and autoimmunity via human production of foreign proteins, contribute to harmful effects. This paper reviews autoimmune, cardiovascular, neurological, potential oncological effects, and autopsy evidence for spikeopathy. With many gene-based therapeutic technologies planned, a re-evaluation is necessary and timely. |
| first_indexed | 2024-03-09T10:55:37Z |
| format | Article |
| id | doaj.art-bc58fe1f00f94018ab6826470686c06c |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:55:37Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-bc58fe1f00f94018ab6826470686c06c2023-12-01T01:42:04ZengMDPI AGBiomedicines2227-90592023-08-01118228710.3390/biomedicines11082287‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNAPeter I. Parry0Astrid Lefringhausen1Conny Turni2Christopher J. Neil3Robyn Cosford4Nicholas J. Hudson5Julian Gillespie6Children’s Health Research Clinical Unit, Faculty of Medicine, The University of Queensland, South Brisbane, QLD 4101, AustraliaChildren’s Health Defence (Australia Chapter), Huskisson, NSW 2540, AustraliaMicrobiology Research, QAAFI (Queensland Alliance for Agriculture and Food Innovation), The University of Queensland, St. Lucia, QLD 4072, AustraliaDepartment of Medicine, University of Melbourne, Melbourne, VIC 3010, AustraliaChildren’s Health Defence (Australia Chapter), Huskisson, NSW 2540, AustraliaSchool of Agriculture and Food Science, The University of Queensland, Brisbane, QLD 4072, AustraliaChildren’s Health Defence (Australia Chapter), Huskisson, NSW 2540, AustraliaThe COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target. Sadly, unprecedented high rates of adverse events have overshadowed the benefits. This two-part narrative review presents evidence for the widespread harms of novel product COVID-19 mRNA and adenovectorDNA vaccines and is novel in attempting to provide a thorough overview of harms arising from the new technology in vaccines that relied on human cells producing a foreign antigen that has evidence of pathogenicity. This first paper explores peer-reviewed data counter to the ‘safe and effective’ narrative attached to these new technologies. Spike protein pathogenicity, termed ‘spikeopathy’, whether from the SARS-CoV-2 virus or produced by vaccine gene codes, akin to a ‘synthetic virus’, is increasingly understood in terms of molecular biology and pathophysiology. Pharmacokinetic transfection through body tissues distant from the injection site by lipid-nanoparticles or viral-vector carriers means that ‘spikeopathy’ can affect many organs. The inflammatory properties of the nanoparticles used to ferry mRNA; N1-methylpseudouridine employed to prolong synthetic mRNA function; the widespread biodistribution of the mRNA and DNA codes and translated spike proteins, and autoimmunity via human production of foreign proteins, contribute to harmful effects. This paper reviews autoimmune, cardiovascular, neurological, potential oncological effects, and autopsy evidence for spikeopathy. With many gene-based therapeutic technologies planned, a re-evaluation is necessary and timely.https://www.mdpi.com/2227-9059/11/8/2287spike proteinpathologytransfectionbiodistributionlipid-nanoparticlesautopsy |
| spellingShingle | Peter I. Parry Astrid Lefringhausen Conny Turni Christopher J. Neil Robyn Cosford Nicholas J. Hudson Julian Gillespie ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA Biomedicines spike protein pathology transfection biodistribution lipid-nanoparticles autopsy |
| title | ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA |
| title_full | ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA |
| title_fullStr | ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA |
| title_full_unstemmed | ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA |
| title_short | ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA |
| title_sort | spikeopathy covid 19 spike protein is pathogenic from both virus and vaccine mrna |
| topic | spike protein pathology transfection biodistribution lipid-nanoparticles autopsy |
| url | https://www.mdpi.com/2227-9059/11/8/2287 |
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