STRUCTURAL AND FUNCTIONAL STATE OF POLYMER COATING OF CORONARY STENTS AFTER EFFECTS OF THE ACCELERATED ELECTRONS FLOW
The article presents the results of investigation of the electron-beam processing effect by a stream of accelerated electrons on coronary stents with a drug coating. Experiments on the visualization of the polymer coating have been carried out, the parameters of the kinetics of the antiproliferative...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2019-02-01
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| Series: | Сибирский научный медицинский журнал |
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| Online Access: | https://sibmed.elpub.ru/jour/article/view/11 |
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| author | P. G. Madonov M. R. Mashkovtsev S. V. Mishenina A. V. Dubrovin P. N. Miroshnikov K. I. Yershov S. V. Pozdnyakova |
| author_facet | P. G. Madonov M. R. Mashkovtsev S. V. Mishenina A. V. Dubrovin P. N. Miroshnikov K. I. Yershov S. V. Pozdnyakova |
| author_sort | P. G. Madonov |
| collection | DOAJ |
| description | The article presents the results of investigation of the electron-beam processing effect by a stream of accelerated electrons on coronary stents with a drug coating. Experiments on the visualization of the polymer coating have been carried out, the parameters of the kinetics of the antiproliferative substance as a function of the radiation dose have been determined. Integrity of the drug-coated stents has been visually assessed by scanning electron microscopy and optical microscopy. The release kinetic have been evaluated by high-performance liquid chromatography method. It has been established that electron beam treatment by the stream of accelerated electrons leads to non-dangerous deformations of the coronary stents drug coating and to the increased yield of antiproliferative substance. Deformation sites of the elution system appear on the surface of the drug-eluting stents after electron-beam treatment by the stream of accelerated electrons at a dose of 1.5 and 3 Mrad. Prolonged diffusion of rapamycin from the treated stent creates concentrations greater than those when used untreated stent and depends on the radiation load in a dose-dependent manner. Stent electron beam treatment by the stream of accelerated electrons provides a high gradient of release of the antiproliferative substance from the elution system, exceeding that without treatment, for 10 days. Comparison of efficiency and safety allows us to consider the technology of electron beam processing as promising for the introduction into coronary stents production. |
| first_indexed | 2024-03-08T14:34:22Z |
| format | Article |
| id | doaj.art-bc59129645054319ba90735d892b170b |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2025-03-14T13:20:12Z |
| publishDate | 2019-02-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-bc59129645054319ba90735d892b170b2025-02-28T13:43:52ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202019-02-01381475210.15372/SSMJ2018010711STRUCTURAL AND FUNCTIONAL STATE OF POLYMER COATING OF CORONARY STENTS AFTER EFFECTS OF THE ACCELERATED ELECTRONS FLOWP. G. Madonov0M. R. Mashkovtsev1S. V. Mishenina2A. V. Dubrovin3P. N. Miroshnikov4K. I. Yershov5S. V. Pozdnyakova6Novosibirsk State Medical University of Minzdrav of RussiaBudker Institute of Nuclear Physics of SB RASNovosibirsk State Medical University of Minzdrav of RussiaNovosibirsk State Medical University of Minzdrav of RussiaNovosibirsk State Medical University of Minzdrav of RussiaNovosibirsk State Medical University of Minzdrav of RussiaNovosibirsk State Medical University of Minzdrav of RussiaThe article presents the results of investigation of the electron-beam processing effect by a stream of accelerated electrons on coronary stents with a drug coating. Experiments on the visualization of the polymer coating have been carried out, the parameters of the kinetics of the antiproliferative substance as a function of the radiation dose have been determined. Integrity of the drug-coated stents has been visually assessed by scanning electron microscopy and optical microscopy. The release kinetic have been evaluated by high-performance liquid chromatography method. It has been established that electron beam treatment by the stream of accelerated electrons leads to non-dangerous deformations of the coronary stents drug coating and to the increased yield of antiproliferative substance. Deformation sites of the elution system appear on the surface of the drug-eluting stents after electron-beam treatment by the stream of accelerated electrons at a dose of 1.5 and 3 Mrad. Prolonged diffusion of rapamycin from the treated stent creates concentrations greater than those when used untreated stent and depends on the radiation load in a dose-dependent manner. Stent electron beam treatment by the stream of accelerated electrons provides a high gradient of release of the antiproliferative substance from the elution system, exceeding that without treatment, for 10 days. Comparison of efficiency and safety allows us to consider the technology of electron beam processing as promising for the introduction into coronary stents production.https://sibmed.elpub.ru/jour/article/view/11coronary stents with drug coatingradiation effect on coronary stentsrelease of antiproliferative drug |
| spellingShingle | P. G. Madonov M. R. Mashkovtsev S. V. Mishenina A. V. Dubrovin P. N. Miroshnikov K. I. Yershov S. V. Pozdnyakova STRUCTURAL AND FUNCTIONAL STATE OF POLYMER COATING OF CORONARY STENTS AFTER EFFECTS OF THE ACCELERATED ELECTRONS FLOW Сибирский научный медицинский журнал coronary stents with drug coating radiation effect on coronary stents release of antiproliferative drug |
| title | STRUCTURAL AND FUNCTIONAL STATE OF POLYMER COATING OF CORONARY STENTS AFTER EFFECTS OF THE ACCELERATED ELECTRONS FLOW |
| title_full | STRUCTURAL AND FUNCTIONAL STATE OF POLYMER COATING OF CORONARY STENTS AFTER EFFECTS OF THE ACCELERATED ELECTRONS FLOW |
| title_fullStr | STRUCTURAL AND FUNCTIONAL STATE OF POLYMER COATING OF CORONARY STENTS AFTER EFFECTS OF THE ACCELERATED ELECTRONS FLOW |
| title_full_unstemmed | STRUCTURAL AND FUNCTIONAL STATE OF POLYMER COATING OF CORONARY STENTS AFTER EFFECTS OF THE ACCELERATED ELECTRONS FLOW |
| title_short | STRUCTURAL AND FUNCTIONAL STATE OF POLYMER COATING OF CORONARY STENTS AFTER EFFECTS OF THE ACCELERATED ELECTRONS FLOW |
| title_sort | structural and functional state of polymer coating of coronary stents after effects of the accelerated electrons flow |
| topic | coronary stents with drug coating radiation effect on coronary stents release of antiproliferative drug |
| url | https://sibmed.elpub.ru/jour/article/view/11 |
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