SIRPα Mismatch Is Associated With Relapse Protection and Chronic Graft-Versus-Host Disease After Related Hematopoietic Stem Cell Transplantation for Lymphoid Malignancies

SIRPα Mismatch Is Associated With Relapse Protection and Chronic Graft-Versus-Host Disease After Related Hematopoietic Stem Cell Transplantation for Lymphoid Malignancies

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematologic malignancies. Alloreactivity after HSCT is known to be mediated by adaptive immune cells expressing rearranging receptors. Recent studies demonstrated that the innate immune system could...

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Bibliographic Details
Main Authors: Rima M. Saliba, Samer A. Srour, Uri Greenbaum, Qing Ma, Yudith Carmazzi, Michael Moller, Janet Wood, Stefan O. Ciurea, Piyanuch Kongtim, Gabriela Rondon, Dan Li, Supawee Saengboon, Amin M. Alousi, Katayoun Rezvani, Elizabeth J. Shpall, Kai Cao, Richard E. Champlin, Jun Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
signal regulatory protein alpha
mismatch
relapse protection
cGVHD
HSCT
lymphoid malignancies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.904718/full

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