The unique interplay of mitochondrial oxidative phosphorylation (OXPHOS) and immunity and its potential implication for the sex‐ and age‐related morbidity of severe COVID‐19 patients

The unique interplay of mitochondrial oxidative phosphorylation (OXPHOS) and immunity and its potential implication for the sex‐ and age‐related morbidity of severe COVID‐19 patients

Abstract Aged male patients are more vulnerable to severe or critical symptoms of COVID‐19, but the underlying mechanism remains elusive. In this study, we analyzed previously published scRNA‐seq data from a large cohort of COVID‐19 patients, castrated and regenerated mice, and bulk RNA‐seq of a RNA...

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Bibliographic Details
Main Authors: Yinchuan Li, Lei Li, Guanghao Wu, Gangcai Xie, Lirong Yi, Jie Zhu, ShiYu Liang, Ya‐ru Huang, Juan Chen, Shaoyang Ji, Fei Sun, Rui‐tian Liu
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:MedComm
Subjects:
androgen
castration
COVID‐19
immunity
oxidative phosphorylation
sex dimorphism
Online Access:https://doi.org/10.1002/mco2.371

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