Clinical–EEG-Neuroimmunological Correlations in Depressive Female Adolescents with Non-Suicidal Self-Injuries
Introduction Non-suicidal self-injurious behavior (NSSI) is rather widespread in adolescents, especially in females, and is an important risk factor for future suicide. The search for neurobiological markers of NSSI is therefore an actual medical and social problem. Objectives The aim of the study...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822008276/type/journal_article |
| _version_ | 1797617597156425728 |
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| author | A. Iznak E. Iznak I. Oleichik S. Zozulya |
| author_facet | A. Iznak E. Iznak I. Oleichik S. Zozulya |
| author_sort | A. Iznak |
| collection | DOAJ |
| description |
Introduction
Non-suicidal self-injurious behavior (NSSI) is rather widespread in adolescents, especially in females, and is an important risk factor for future suicide. The search for neurobiological markers of NSSI is therefore an actual medical and social problem.
Objectives
The aim of the study was to determine the relationships between pre-treatment quantitative clinical, EEG, and neuroimmunological parameters in female depressive adolescents with NSSI.
Methods
40 female depressive patients (all right-handed, 16–25 years old, mean 17.6±2.2 years old) were included in the study. Total HDRS-17 scores varied from 14 to 38 (mean 26.0±6.9). Multichannel eyes closed resting EEG was recorded with subsequent spectral power (SP) measurements in narrow frequency sub-bands. Enzymatic activities of leukocyte elastase (LE) and its antagonist α-1 proteinase inhibitor (α1-PI), as neuroinflammation markers, and the levels of autoantibodies to S100b protein (AAB-S100b) and to basic myelin protein (AAB-BMP), as neuroplasticity markers, were measured in the blood plasma. Spearman’s rank correlations were calculated between clinical, EEG, and neuroimmunological parameters.
Results
HDRS-17 scores correlated positively (p<0.05) with beta2 (20-30 Hz) SP in the right anterior and mid-temporal leads. AAB-S100b values correlated positively with alpha2 (9-11 Hz) and alpha3 (11-13 Hz) SP in central-temporal-parietal-occipital leads, and correlated negatively with beta1 (13-20 Hz) and beta2 SP in the right anterior temporal lead.
Conclusions
The structure of clinical–neurobiological correlations obtained indicates that processes of neuroinflammation in depressive adolescents with NSSI are relatively mild and/or compensated by anti-inflammatory mechanisms. The study supported by RBRF grant No.20-013-00129a.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:57:06Z |
| format | Article |
| id | doaj.art-bc610d0f047044da9e4074c974bedb5f |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:57:06Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-bc610d0f047044da9e4074c974bedb5f2023-11-17T05:05:26ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S325S32510.1192/j.eurpsy.2022.827Clinical–EEG-Neuroimmunological Correlations in Depressive Female Adolescents with Non-Suicidal Self-InjuriesA. Iznak0E. Iznak1I. Oleichik2S. Zozulya3Mental Health Research Centre, Laboratory Of Neurophysiology, Moscow, Russian FederationMental Health Research Centre, Laboratory Of Neurophysiology, Moscow, Russian FederationMental Health Research Centre, Department Of Endogenous Mental Disorders And Affective Conditions, Moscow, Russian FederationMental Health Research Centre, Laboratory Of Neuroimmunology, Moscow, Russian Federation Introduction Non-suicidal self-injurious behavior (NSSI) is rather widespread in adolescents, especially in females, and is an important risk factor for future suicide. The search for neurobiological markers of NSSI is therefore an actual medical and social problem. Objectives The aim of the study was to determine the relationships between pre-treatment quantitative clinical, EEG, and neuroimmunological parameters in female depressive adolescents with NSSI. Methods 40 female depressive patients (all right-handed, 16–25 years old, mean 17.6±2.2 years old) were included in the study. Total HDRS-17 scores varied from 14 to 38 (mean 26.0±6.9). Multichannel eyes closed resting EEG was recorded with subsequent spectral power (SP) measurements in narrow frequency sub-bands. Enzymatic activities of leukocyte elastase (LE) and its antagonist α-1 proteinase inhibitor (α1-PI), as neuroinflammation markers, and the levels of autoantibodies to S100b protein (AAB-S100b) and to basic myelin protein (AAB-BMP), as neuroplasticity markers, were measured in the blood plasma. Spearman’s rank correlations were calculated between clinical, EEG, and neuroimmunological parameters. Results HDRS-17 scores correlated positively (p<0.05) with beta2 (20-30 Hz) SP in the right anterior and mid-temporal leads. AAB-S100b values correlated positively with alpha2 (9-11 Hz) and alpha3 (11-13 Hz) SP in central-temporal-parietal-occipital leads, and correlated negatively with beta1 (13-20 Hz) and beta2 SP in the right anterior temporal lead. Conclusions The structure of clinical–neurobiological correlations obtained indicates that processes of neuroinflammation in depressive adolescents with NSSI are relatively mild and/or compensated by anti-inflammatory mechanisms. The study supported by RBRF grant No.20-013-00129a. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822008276/type/journal_articleAdolescentsnon-suicidal self-injuriesquantitative EEGneuroimmunology |
| spellingShingle | A. Iznak E. Iznak I. Oleichik S. Zozulya Clinical–EEG-Neuroimmunological Correlations in Depressive Female Adolescents with Non-Suicidal Self-Injuries European Psychiatry Adolescents non-suicidal self-injuries quantitative EEG neuroimmunology |
| title | Clinical–EEG-Neuroimmunological Correlations in Depressive Female Adolescents with Non-Suicidal Self-Injuries |
| title_full | Clinical–EEG-Neuroimmunological Correlations in Depressive Female Adolescents with Non-Suicidal Self-Injuries |
| title_fullStr | Clinical–EEG-Neuroimmunological Correlations in Depressive Female Adolescents with Non-Suicidal Self-Injuries |
| title_full_unstemmed | Clinical–EEG-Neuroimmunological Correlations in Depressive Female Adolescents with Non-Suicidal Self-Injuries |
| title_short | Clinical–EEG-Neuroimmunological Correlations in Depressive Female Adolescents with Non-Suicidal Self-Injuries |
| title_sort | clinical eeg neuroimmunological correlations in depressive female adolescents with non suicidal self injuries |
| topic | Adolescents non-suicidal self-injuries quantitative EEG neuroimmunology |
| url | https://www.cambridge.org/core/product/identifier/S0924933822008276/type/journal_article |
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