Plasticity of face–hand sensorimotor circuits after a traumatic brachial plexus injury
BackgroundInteractions between the somatosensory and motor cortices are of fundamental importance for motor control. Although physically distant, face and hand representations are side by side in the sensorimotor cortex and interact functionally. Traumatic brachial plexus injury (TBPI) interferes wi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1221777/full |
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| author | Fernanda de Figueiredo Torres Fernanda de Figueiredo Torres Bia Lima Ramalho Bia Lima Ramalho Bia Lima Ramalho Marcelle Ribeiro Rodrigues Marcelle Ribeiro Rodrigues Ana Carolina Schmaedeke Ana Carolina Schmaedeke Victor Hugo Moraes Victor Hugo Moraes Karen T. Reilly Karen T. Reilly Raquel de Paula Carvalho Raquel de Paula Carvalho Raquel de Paula Carvalho Claudia D. Vargas Claudia D. Vargas Claudia D. Vargas |
| author_facet | Fernanda de Figueiredo Torres Fernanda de Figueiredo Torres Bia Lima Ramalho Bia Lima Ramalho Bia Lima Ramalho Marcelle Ribeiro Rodrigues Marcelle Ribeiro Rodrigues Ana Carolina Schmaedeke Ana Carolina Schmaedeke Victor Hugo Moraes Victor Hugo Moraes Karen T. Reilly Karen T. Reilly Raquel de Paula Carvalho Raquel de Paula Carvalho Raquel de Paula Carvalho Claudia D. Vargas Claudia D. Vargas Claudia D. Vargas |
| author_sort | Fernanda de Figueiredo Torres |
| collection | DOAJ |
| description | BackgroundInteractions between the somatosensory and motor cortices are of fundamental importance for motor control. Although physically distant, face and hand representations are side by side in the sensorimotor cortex and interact functionally. Traumatic brachial plexus injury (TBPI) interferes with upper limb sensorimotor function, causes bilateral cortical reorganization, and is associated with chronic pain. Thus, TBPI may affect sensorimotor interactions between face and hand representations.ObjectiveThe aim of this study was to investigate changes in hand–hand and face–hand sensorimotor integration in TBPI patients using an afferent inhibition (AI) paradigm.MethodThe experimental design consisted of electrical stimulation (ES) applied to the hand or face followed by transcranial magnetic stimulation (TMS) to the primary motor cortex to activate a hand muscle representation. In the AI paradigm, the motor evoked potential (MEP) in a target muscle is significantly reduced when preceded by an ES at short-latency (SAI) or long-latency (LAI) interstimulus intervals. We tested 18 healthy adults (control group, CG), evaluated on the dominant upper limb, and nine TBPI patients, evaluated on the injured or the uninjured limb. A detailed clinical evaluation complemented the physiological investigation.ResultsAlthough hand–hand SAI was present in both the CG and the TBPI groups, hand–hand LAI was present in the CG only. Moreover, less AI was observed in TBPI patients than the CG both for face–hand SAI and LAI.ConclusionOur results indicate that sensorimotor integration involving both hand and face sensorimotor representations is affected by TBPI. |
| first_indexed | 2024-03-12T17:00:06Z |
| format | Article |
| id | doaj.art-bc61e8a92d854e548c6502b3b239c5af |
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| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-12T17:00:06Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-bc61e8a92d854e548c6502b3b239c5af2023-08-07T15:53:43ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-08-011710.3389/fnins.2023.12217771221777Plasticity of face–hand sensorimotor circuits after a traumatic brachial plexus injuryFernanda de Figueiredo Torres0Fernanda de Figueiredo Torres1Bia Lima Ramalho2Bia Lima Ramalho3Bia Lima Ramalho4Marcelle Ribeiro Rodrigues5Marcelle Ribeiro Rodrigues6Ana Carolina Schmaedeke7Ana Carolina Schmaedeke8Victor Hugo Moraes9Victor Hugo Moraes10Karen T. Reilly11Karen T. Reilly12Raquel de Paula Carvalho13Raquel de Paula Carvalho14Raquel de Paula Carvalho15Claudia D. Vargas16Claudia D. Vargas17Claudia D. Vargas18Laboratory of Neurobiology of Movement, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Neuroscience and Rehabilitation, Institute of Neurology Deolindo Couto, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Neurobiology of Movement, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Neuroscience and Rehabilitation, Institute of Neurology Deolindo Couto, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilResearch, Innovation and Dissemination Center for Neuromathematics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, BrazilLaboratory of Neurobiology of Movement, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Neuroscience and Rehabilitation, Institute of Neurology Deolindo Couto, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Neurobiology of Movement, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Neuroscience and Rehabilitation, Institute of Neurology Deolindo Couto, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Neurobiology of Movement, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Neuroscience and Rehabilitation, Institute of Neurology Deolindo Couto, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilTrajectoires Team, Lyon Neuroscience Research Center, Lyon, FranceUniversity UCBL Lyon 1, University of Lyon, Lyon, FranceLaboratory of Neuroscience and Rehabilitation, Institute of Neurology Deolindo Couto, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilResearch, Innovation and Dissemination Center for Neuromathematics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, BrazilLaboratory of Child Development and Motricity, Department of Human Movement Science, Institute of Health and Society, Universidade Federal de São Paulo, Santos, BrazilLaboratory of Neurobiology of Movement, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Neuroscience and Rehabilitation, Institute of Neurology Deolindo Couto, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilResearch, Innovation and Dissemination Center for Neuromathematics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, BrazilBackgroundInteractions between the somatosensory and motor cortices are of fundamental importance for motor control. Although physically distant, face and hand representations are side by side in the sensorimotor cortex and interact functionally. Traumatic brachial plexus injury (TBPI) interferes with upper limb sensorimotor function, causes bilateral cortical reorganization, and is associated with chronic pain. Thus, TBPI may affect sensorimotor interactions between face and hand representations.ObjectiveThe aim of this study was to investigate changes in hand–hand and face–hand sensorimotor integration in TBPI patients using an afferent inhibition (AI) paradigm.MethodThe experimental design consisted of electrical stimulation (ES) applied to the hand or face followed by transcranial magnetic stimulation (TMS) to the primary motor cortex to activate a hand muscle representation. In the AI paradigm, the motor evoked potential (MEP) in a target muscle is significantly reduced when preceded by an ES at short-latency (SAI) or long-latency (LAI) interstimulus intervals. We tested 18 healthy adults (control group, CG), evaluated on the dominant upper limb, and nine TBPI patients, evaluated on the injured or the uninjured limb. A detailed clinical evaluation complemented the physiological investigation.ResultsAlthough hand–hand SAI was present in both the CG and the TBPI groups, hand–hand LAI was present in the CG only. Moreover, less AI was observed in TBPI patients than the CG both for face–hand SAI and LAI.ConclusionOur results indicate that sensorimotor integration involving both hand and face sensorimotor representations is affected by TBPI.https://www.frontiersin.org/articles/10.3389/fnins.2023.1221777/fullafferent inhibitioncorticospinal excitabilitytranscranial magnetic stimulationbrachial plexus lesiondeafferentationpain |
| spellingShingle | Fernanda de Figueiredo Torres Fernanda de Figueiredo Torres Bia Lima Ramalho Bia Lima Ramalho Bia Lima Ramalho Marcelle Ribeiro Rodrigues Marcelle Ribeiro Rodrigues Ana Carolina Schmaedeke Ana Carolina Schmaedeke Victor Hugo Moraes Victor Hugo Moraes Karen T. Reilly Karen T. Reilly Raquel de Paula Carvalho Raquel de Paula Carvalho Raquel de Paula Carvalho Claudia D. Vargas Claudia D. Vargas Claudia D. Vargas Plasticity of face–hand sensorimotor circuits after a traumatic brachial plexus injury Frontiers in Neuroscience afferent inhibition corticospinal excitability transcranial magnetic stimulation brachial plexus lesion deafferentation pain |
| title | Plasticity of face–hand sensorimotor circuits after a traumatic brachial plexus injury |
| title_full | Plasticity of face–hand sensorimotor circuits after a traumatic brachial plexus injury |
| title_fullStr | Plasticity of face–hand sensorimotor circuits after a traumatic brachial plexus injury |
| title_full_unstemmed | Plasticity of face–hand sensorimotor circuits after a traumatic brachial plexus injury |
| title_short | Plasticity of face–hand sensorimotor circuits after a traumatic brachial plexus injury |
| title_sort | plasticity of face hand sensorimotor circuits after a traumatic brachial plexus injury |
| topic | afferent inhibition corticospinal excitability transcranial magnetic stimulation brachial plexus lesion deafferentation pain |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1221777/full |
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