Greener Synthesis, In-Silico and Theoretical Analysis of Hydrazides as Potential Antituberculosis Agents (Part 1)
Since several decades, our healthcare burden has been increased due to tremendous cases of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) infections, especially in tropical countries. In the present study, we have synthesized ten hydrazides with the use of the gree...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Chemistry Proceedings |
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| Online Access: | https://www.mdpi.com/2673-4583/8/1/86 |
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| author | Suraj N. Mali Anima Pandey Bapu R. Thorat Chin-Hung Lai |
| author_facet | Suraj N. Mali Anima Pandey Bapu R. Thorat Chin-Hung Lai |
| author_sort | Suraj N. Mali |
| collection | DOAJ |
| description | Since several decades, our healthcare burden has been increased due to tremendous cases of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) infections, especially in tropical countries. In the present study, we have synthesized ten hydrazides with the use of the greener Chitosan-derived catalyst. This catalyst accomplished the said condensation reaction within 15–30 min at room temperature conditions. All our synthesized compounds showed stronger affinities against <i>Mycobacterium tb</i> and bacterial targets, especially towards 1d7u, than the standard drug ciprofloxacin. One of our compounds retained a lower toxicity (electrophilicity index (ω) 3.1304), low chemical hardness (η: 2.1740), and high softness (S: 0.4600). In the realm of the development of more potent, effective, and safe antituberculosis agents with an effective greener synthesis, our current study would provide more insights on potent analogues containing hydrazine motifs in them. |
| first_indexed | 2024-03-11T06:46:01Z |
| format | Article |
| id | doaj.art-bc6416ce1d7b4035b9614a5fc4f2ef03 |
| institution | Directory Open Access Journal |
| issn | 2673-4583 |
| language | English |
| last_indexed | 2024-03-11T06:46:01Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry Proceedings |
| spelling | doaj.art-bc6416ce1d7b4035b9614a5fc4f2ef032023-11-17T10:19:13ZengMDPI AGChemistry Proceedings2673-45832021-11-01818610.3390/ecsoc-25-11655Greener Synthesis, In-Silico and Theoretical Analysis of Hydrazides as Potential Antituberculosis Agents (Part 1)Suraj N. Mali0Anima Pandey1Bapu R. Thorat2Chin-Hung Lai3Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, IndiaDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, IndiaDepartment of Chemistry, Government College of Arts and Science, Aurangabad 431004, IndiaDepartment of Medical Applied Chemistry, Chung Shan Medical University, Taichung 40241, TaiwanSince several decades, our healthcare burden has been increased due to tremendous cases of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) infections, especially in tropical countries. In the present study, we have synthesized ten hydrazides with the use of the greener Chitosan-derived catalyst. This catalyst accomplished the said condensation reaction within 15–30 min at room temperature conditions. All our synthesized compounds showed stronger affinities against <i>Mycobacterium tb</i> and bacterial targets, especially towards 1d7u, than the standard drug ciprofloxacin. One of our compounds retained a lower toxicity (electrophilicity index (ω) 3.1304), low chemical hardness (η: 2.1740), and high softness (S: 0.4600). In the realm of the development of more potent, effective, and safe antituberculosis agents with an effective greener synthesis, our current study would provide more insights on potent analogues containing hydrazine motifs in them.https://www.mdpi.com/2673-4583/8/1/86hydrazide-hydrazonesantituberculosis activityin-silico analysistuberculosissynthesismolecular modelling |
| spellingShingle | Suraj N. Mali Anima Pandey Bapu R. Thorat Chin-Hung Lai Greener Synthesis, In-Silico and Theoretical Analysis of Hydrazides as Potential Antituberculosis Agents (Part 1) Chemistry Proceedings hydrazide-hydrazones antituberculosis activity in-silico analysis tuberculosis synthesis molecular modelling |
| title | Greener Synthesis, In-Silico and Theoretical Analysis of Hydrazides as Potential Antituberculosis Agents (Part 1) |
| title_full | Greener Synthesis, In-Silico and Theoretical Analysis of Hydrazides as Potential Antituberculosis Agents (Part 1) |
| title_fullStr | Greener Synthesis, In-Silico and Theoretical Analysis of Hydrazides as Potential Antituberculosis Agents (Part 1) |
| title_full_unstemmed | Greener Synthesis, In-Silico and Theoretical Analysis of Hydrazides as Potential Antituberculosis Agents (Part 1) |
| title_short | Greener Synthesis, In-Silico and Theoretical Analysis of Hydrazides as Potential Antituberculosis Agents (Part 1) |
| title_sort | greener synthesis in silico and theoretical analysis of hydrazides as potential antituberculosis agents part 1 |
| topic | hydrazide-hydrazones antituberculosis activity in-silico analysis tuberculosis synthesis molecular modelling |
| url | https://www.mdpi.com/2673-4583/8/1/86 |
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