Complement Activation-Related Pathophysiological Changes in Anesthetized Rats: Activator-Dependent Variations of Symptoms and Mediators of Pseudoallergy

Complement Activation-Related Pathophysiological Changes in Anesthetized Rats: Activator-Dependent Variations of Symptoms and Mediators of Pseudoallergy

Complement (C) activation can underlie the infusion reactions to liposomes and other nanoparticle-based medicines, a hypersensitivity syndrome that can be partially reproduced in animal models. However, the sensitivities and manifestations substantially differ in different species, and C activation...

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Bibliographic Details
Main Authors: László Dézsi, Tamás Mészáros, Erik Őrfi, Tamás G. Fülöp, Mark Hennies, László Rosivall, Péter Hamar, János Szebeni, Gábor Szénási
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
complement activation
infusion reactions
zymosan
cobra venom factor
amphotericin B
blood pressure
blood cell count
thromboxane
Online Access:https://www.mdpi.com/1420-3049/24/18/3283

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