Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine
The sleep-wake cycle is regulated by a fine-tuned interplay between sleep-homeostatic and circadian mechanisms. Compelling evidence suggests that adenosine plays an important role in mediating the increase of homeostatic sleep pressure during time spent awake and its decrease during sleep. Here, we...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-02-01
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| Series: | Biology |
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| Online Access: | http://www.mdpi.com/2079-7737/5/1/11 |
| _version_ | 1797726879607685120 |
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| author | Carolin Franziska Reichert Micheline Maire Christina Schmidt Christian Cajochen |
| author_facet | Carolin Franziska Reichert Micheline Maire Christina Schmidt Christian Cajochen |
| author_sort | Carolin Franziska Reichert |
| collection | DOAJ |
| description | The sleep-wake cycle is regulated by a fine-tuned interplay between sleep-homeostatic and circadian mechanisms. Compelling evidence suggests that adenosine plays an important role in mediating the increase of homeostatic sleep pressure during time spent awake and its decrease during sleep. Here, we summarize evidence that adenosinergic mechanisms regulate not only the dynamic of sleep pressure, but are also implicated in the interaction of homeostatic and circadian processes. We review how this interaction becomes evident at several levels, including electrophysiological data, neuroimaging studies and behavioral observations. Regarding complex human behavior, we particularly focus on sleep-wake regulatory influences on working memory performance and underlying brain activity, with a specific emphasis on the role of adenosine in this interplay. We conclude that a change in adenosinergic mechanisms, whether exogenous or endogenous, does not only impact on sleep-homeostatic processes, but also interferes with the circadian timing system. |
| first_indexed | 2024-03-12T10:51:49Z |
| format | Article |
| id | doaj.art-bc67870fd6a5490685ec72e83d9b2ca8 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T10:51:49Z |
| publishDate | 2016-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-bc67870fd6a5490685ec72e83d9b2ca82023-09-02T06:52:57ZengMDPI AGBiology2079-77372016-02-01511110.3390/biology5010011biology5010011Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of AdenosineCarolin Franziska Reichert0Micheline Maire1Christina Schmidt2Christian Cajochen3Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Wilhelm Klein-Strasse 27, Basel 4012, SwitzerlandCentre for Chronobiology, Psychiatric Hospital of the University of Basel, Wilhelm Klein-Strasse 27, Basel 4012, SwitzerlandCyclotron Research Centre, University of Liège, Allée du 6 Août n°8, Liège 4000, BelgiumCentre for Chronobiology, Psychiatric Hospital of the University of Basel, Wilhelm Klein-Strasse 27, Basel 4012, SwitzerlandThe sleep-wake cycle is regulated by a fine-tuned interplay between sleep-homeostatic and circadian mechanisms. Compelling evidence suggests that adenosine plays an important role in mediating the increase of homeostatic sleep pressure during time spent awake and its decrease during sleep. Here, we summarize evidence that adenosinergic mechanisms regulate not only the dynamic of sleep pressure, but are also implicated in the interaction of homeostatic and circadian processes. We review how this interaction becomes evident at several levels, including electrophysiological data, neuroimaging studies and behavioral observations. Regarding complex human behavior, we particularly focus on sleep-wake regulatory influences on working memory performance and underlying brain activity, with a specific emphasis on the role of adenosine in this interplay. We conclude that a change in adenosinergic mechanisms, whether exogenous or endogenous, does not only impact on sleep-homeostatic processes, but also interferes with the circadian timing system.http://www.mdpi.com/2079-7737/5/1/11circadiansleep homeostasisadenosineworking memorycognition |
| spellingShingle | Carolin Franziska Reichert Micheline Maire Christina Schmidt Christian Cajochen Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine Biology circadian sleep homeostasis adenosine working memory cognition |
| title | Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine |
| title_full | Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine |
| title_fullStr | Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine |
| title_full_unstemmed | Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine |
| title_short | Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine |
| title_sort | sleep wake regulation and its impact on working memory performance the role of adenosine |
| topic | circadian sleep homeostasis adenosine working memory cognition |
| url | http://www.mdpi.com/2079-7737/5/1/11 |
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