Concomitant Infection of <i>Helicobacter pylori</i> and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy
Background: <i>Helicobacter pylori</i> and intestinal parasites are estimated to infect with high burden worldwide. However, their concomitant infections are poorly determined in industrialized countries, such as Italy. In this study we aim at describing the presence of <i>H. pylor...
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MDPI AG
2020-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/8/2366 |
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| author | Elena Pomari Tamara Ursini Ronaldo Silva Martina Leonardi Marco Ligozzi Andrea Angheben |
| author_facet | Elena Pomari Tamara Ursini Ronaldo Silva Martina Leonardi Marco Ligozzi Andrea Angheben |
| author_sort | Elena Pomari |
| collection | DOAJ |
| description | Background: <i>Helicobacter pylori</i> and intestinal parasites are estimated to infect with high burden worldwide. However, their concomitant infections are poorly determined in industrialized countries, such as Italy. In this study we aim at describing the presence of <i>H. pylori</i> as well as the proportion of coinfections with intestinal parasites among subjects who attended a referral center for tropical diseases in Northern Italy. Methods: This was a case-control study. Screening for <i>H. pylori</i> and parasites was performed on stool samples of 93 adults from different geographical origin (Africa, Asia, South-America, East-Europe and Italy). <i>H. pylori</i> infection was examined by CLIA and its <i>cagA</i> positivity was determined by rtPCR. Intestinal parasites (i.e., protozoa and helminths) were examined by microscopy and rtPCR. Results: Sixty-one out of 93 patients (66%) were positive to <i>H. pylori</i> and 31 (33%) were <i>cagA</i>+. Among <i>H. pylori</i> positives, 45 (74%) had a concomitant infection. The coinfection <i>H. pylori</i>–<i>Blastocystis</i> was the most frequent one, followed by <i>H. pylori–E. coli</i>. Multivariable logistic regression showed that positivity to <i>H. pylori</i> was associated with having a coinfection. Conclusion: Our data suggested that <i>H. pylori</i> and intestinal parasitic infections are fairly common in subjects who attended a referral center for tropical diseases in Northern Italy. The high rate of <i>H. pylori</i> infection, and especially the positivity to the virulent <i>cagA</i>+, should be taken into consideration in subjects undergoing screening for parasitic infections. |
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| language | English |
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| publishDate | 2020-07-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-bc6870b8c5644a5b91a63976062eb4d42023-11-20T07:50:12ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0198236610.3390/jcm9082366Concomitant Infection of <i>Helicobacter pylori</i> and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern ItalyElena Pomari0Tamara Ursini1Ronaldo Silva2Martina Leonardi3Marco Ligozzi4Andrea Angheben5Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, ItalyDepartment of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, ItalyDepartment of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, ItalyDepartment of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, ItalyDepartment of Diagnostics and Public Health, University of Verona, 37134 Verona, ItalyDepartment of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, ItalyBackground: <i>Helicobacter pylori</i> and intestinal parasites are estimated to infect with high burden worldwide. However, their concomitant infections are poorly determined in industrialized countries, such as Italy. In this study we aim at describing the presence of <i>H. pylori</i> as well as the proportion of coinfections with intestinal parasites among subjects who attended a referral center for tropical diseases in Northern Italy. Methods: This was a case-control study. Screening for <i>H. pylori</i> and parasites was performed on stool samples of 93 adults from different geographical origin (Africa, Asia, South-America, East-Europe and Italy). <i>H. pylori</i> infection was examined by CLIA and its <i>cagA</i> positivity was determined by rtPCR. Intestinal parasites (i.e., protozoa and helminths) were examined by microscopy and rtPCR. Results: Sixty-one out of 93 patients (66%) were positive to <i>H. pylori</i> and 31 (33%) were <i>cagA</i>+. Among <i>H. pylori</i> positives, 45 (74%) had a concomitant infection. The coinfection <i>H. pylori</i>–<i>Blastocystis</i> was the most frequent one, followed by <i>H. pylori–E. coli</i>. Multivariable logistic regression showed that positivity to <i>H. pylori</i> was associated with having a coinfection. Conclusion: Our data suggested that <i>H. pylori</i> and intestinal parasitic infections are fairly common in subjects who attended a referral center for tropical diseases in Northern Italy. The high rate of <i>H. pylori</i> infection, and especially the positivity to the virulent <i>cagA</i>+, should be taken into consideration in subjects undergoing screening for parasitic infections.https://www.mdpi.com/2077-0383/9/8/2366<i>Helicobacter pylori</i>intestinal parasitescoinfectionItaly |
| spellingShingle | Elena Pomari Tamara Ursini Ronaldo Silva Martina Leonardi Marco Ligozzi Andrea Angheben Concomitant Infection of <i>Helicobacter pylori</i> and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy Journal of Clinical Medicine <i>Helicobacter pylori</i> intestinal parasites coinfection Italy |
| title | Concomitant Infection of <i>Helicobacter pylori</i> and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy |
| title_full | Concomitant Infection of <i>Helicobacter pylori</i> and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy |
| title_fullStr | Concomitant Infection of <i>Helicobacter pylori</i> and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy |
| title_full_unstemmed | Concomitant Infection of <i>Helicobacter pylori</i> and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy |
| title_short | Concomitant Infection of <i>Helicobacter pylori</i> and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy |
| title_sort | concomitant infection of i helicobacter pylori i and intestinal parasites in adults attending a referral centre for parasitic infections in north eastern italy |
| topic | <i>Helicobacter pylori</i> intestinal parasites coinfection Italy |
| url | https://www.mdpi.com/2077-0383/9/8/2366 |
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