Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital
Antimicrobial resistance (AMR) presents a growing threat to global healthcare. This descriptive epidemiological study investigates the prevalence and characteristics of Enterobacterales with AMR factors in a tertiary teaching hospital in Italy over the course of the year 2021. In 2021, the prevalenc...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/9/1140 |
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| author | Erica De Vita Luigi De Angelis Guglielmo Arzilli Francesco Baglivo Simona Barnini Alessandra Vecchione Angelo Baggiani Caterina Rizzo Andrea Davide Porretta Teams AID |
| author_facet | Erica De Vita Luigi De Angelis Guglielmo Arzilli Francesco Baglivo Simona Barnini Alessandra Vecchione Angelo Baggiani Caterina Rizzo Andrea Davide Porretta Teams AID |
| author_sort | Erica De Vita |
| collection | DOAJ |
| description | Antimicrobial resistance (AMR) presents a growing threat to global healthcare. This descriptive epidemiological study investigates the prevalence and characteristics of Enterobacterales with AMR factors in a tertiary teaching hospital in Italy over the course of the year 2021. In 2021, the prevalence of colonisation by Enterobacterales with AMR factors in patients was 1.08%. During the observation period, a total of 8834 rectal swabs were performed, with 1453 testing positive. A total of 5639 rectal swabs were performed according to a hospital procedure for the active screening of MDRO colonisation at the time of admission. Of these, 679 were positive for microorganisms under surveillance, and 74 patients were colonised with Enterobacterales, predominantly <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i>. Antibiotic resistance factors were observed in 61 of these 74 patients (82.43%) of these patients, with NDM and KPC being the most frequent resistance factors. A statistically significant trend in positive swabs was observed across different ward categories (surgery, ICUs, and medical wards). Regarding specific trends, the rate of positive admission screening in medical and surgical wards was higher than in ICU wards. The results highlight the ease with which Enterobacterales develops resistance across different ward categories. The findings underscore the need for adjusted screening protocols and tailored infection prevention strategies in various care settings. |
| first_indexed | 2024-03-10T22:18:41Z |
| format | Article |
| id | doaj.art-bc69e7b64ac241e4a9e54733ab999f9a |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T22:18:41Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-bc69e7b64ac241e4a9e54733ab999f9a2023-11-19T12:22:37ZengMDPI AGPathogens2076-08172023-09-01129114010.3390/pathogens12091140Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching HospitalErica De Vita0Luigi De Angelis1Guglielmo Arzilli2Francesco Baglivo3Simona Barnini4Alessandra Vecchione5Angelo Baggiani6Caterina Rizzo7Andrea Davide Porretta8Teams AID9Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56123 Pisa, ItalyDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56123 Pisa, ItalyDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56123 Pisa, ItalyDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56123 Pisa, ItalyMicrobiology Unit, University Hospital of Pisa, 56124 Pisa, ItalyMicrobiology Unit, University Hospital of Pisa, 56124 Pisa, ItalyDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56123 Pisa, ItalyDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56123 Pisa, ItalyDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56123 Pisa, ItalyUniversity Hospital of Pisa, 56123 Pisa, ItalyAntimicrobial resistance (AMR) presents a growing threat to global healthcare. This descriptive epidemiological study investigates the prevalence and characteristics of Enterobacterales with AMR factors in a tertiary teaching hospital in Italy over the course of the year 2021. In 2021, the prevalence of colonisation by Enterobacterales with AMR factors in patients was 1.08%. During the observation period, a total of 8834 rectal swabs were performed, with 1453 testing positive. A total of 5639 rectal swabs were performed according to a hospital procedure for the active screening of MDRO colonisation at the time of admission. Of these, 679 were positive for microorganisms under surveillance, and 74 patients were colonised with Enterobacterales, predominantly <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i>. Antibiotic resistance factors were observed in 61 of these 74 patients (82.43%) of these patients, with NDM and KPC being the most frequent resistance factors. A statistically significant trend in positive swabs was observed across different ward categories (surgery, ICUs, and medical wards). Regarding specific trends, the rate of positive admission screening in medical and surgical wards was higher than in ICU wards. The results highlight the ease with which Enterobacterales develops resistance across different ward categories. The findings underscore the need for adjusted screening protocols and tailored infection prevention strategies in various care settings.https://www.mdpi.com/2076-0817/12/9/1140antimicrobial resistance (AMR)enterobacteralesrectal swabshospital screeningcarbapenem-resistant enterobacterales (CRE)infection control |
| spellingShingle | Erica De Vita Luigi De Angelis Guglielmo Arzilli Francesco Baglivo Simona Barnini Alessandra Vecchione Angelo Baggiani Caterina Rizzo Andrea Davide Porretta Teams AID Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital Pathogens antimicrobial resistance (AMR) enterobacterales rectal swabs hospital screening carbapenem-resistant enterobacterales (CRE) infection control |
| title | Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital |
| title_full | Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital |
| title_fullStr | Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital |
| title_full_unstemmed | Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital |
| title_short | Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital |
| title_sort | investigating resistance to carbapenems in enterobacterales a descriptive epidemiological study of 2021 screening in an italian teaching hospital |
| topic | antimicrobial resistance (AMR) enterobacterales rectal swabs hospital screening carbapenem-resistant enterobacterales (CRE) infection control |
| url | https://www.mdpi.com/2076-0817/12/9/1140 |
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