Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis
Rhabdomyoma is the most common fetal cardiac tumor, and its development is related to tuberous sclerosis. Fetal cardiac rhabdomyomas often spontaneously regress in utero or after birth, but large tumors can cause hemodynamic obstruction. Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, h...
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| Format: | Article |
| Language: | English |
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Korean Society of Obstetrics and Gynecology
2019-07-01
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| Series: | Obstetrics & Gynecology Science |
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| Online Access: | http://ogscience.org/upload/pdf/ogs-62-280.pdf |
| _version_ | 1818131517698736128 |
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| author | Hyea Park Chi Son Chang Suk-Joo Choi Soo-young Oh Cheong-Rae Roh |
| author_facet | Hyea Park Chi Son Chang Suk-Joo Choi Soo-young Oh Cheong-Rae Roh |
| author_sort | Hyea Park |
| collection | DOAJ |
| description | Rhabdomyoma is the most common fetal cardiac tumor, and its development is related to tuberous sclerosis. Fetal cardiac rhabdomyomas often spontaneously regress in utero or after birth, but large tumors can cause hemodynamic obstruction. Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been used as an immunosuppressant after organ transplantation. The mTOR inhibitors are well-known to have anti-tumor activity, and they have been used for the treatment of patients with tuberous sclerosis. In the current case, fetal cardiac rhabdomyoma was completely resolved in utero during oral sirolimus treatment in the mother with tuberous sclerosis. This case shows that oral sirolimus therapy in pregnancy may be a treatment for multiple or large fetal cardiac rhabdomyomas. |
| first_indexed | 2024-12-11T08:22:12Z |
| format | Article |
| id | doaj.art-bc6aa171bb76459a87a41fbda434fa45 |
| institution | Directory Open Access Journal |
| issn | 2287-8572 2287-8580 |
| language | English |
| last_indexed | 2024-12-11T08:22:12Z |
| publishDate | 2019-07-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj.art-bc6aa171bb76459a87a41fbda434fa452022-12-22T01:14:39ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802019-07-0162428028410.5468/ogs.2019.62.4.280586Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosisHyea Park0Chi Son Chang1Suk-Joo Choi2Soo-young Oh3Cheong-Rae Roh4Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, .KoreaRhabdomyoma is the most common fetal cardiac tumor, and its development is related to tuberous sclerosis. Fetal cardiac rhabdomyomas often spontaneously regress in utero or after birth, but large tumors can cause hemodynamic obstruction. Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been used as an immunosuppressant after organ transplantation. The mTOR inhibitors are well-known to have anti-tumor activity, and they have been used for the treatment of patients with tuberous sclerosis. In the current case, fetal cardiac rhabdomyoma was completely resolved in utero during oral sirolimus treatment in the mother with tuberous sclerosis. This case shows that oral sirolimus therapy in pregnancy may be a treatment for multiple or large fetal cardiac rhabdomyomas.http://ogscience.org/upload/pdf/ogs-62-280.pdfsirolimuscardiac tumorrhabdomyomatuberous sclerosisfetal therapy |
| spellingShingle | Hyea Park Chi Son Chang Suk-Joo Choi Soo-young Oh Cheong-Rae Roh Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis Obstetrics & Gynecology Science sirolimus cardiac tumor rhabdomyoma tuberous sclerosis fetal therapy |
| title | Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis |
| title_full | Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis |
| title_fullStr | Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis |
| title_full_unstemmed | Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis |
| title_short | Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis |
| title_sort | sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis |
| topic | sirolimus cardiac tumor rhabdomyoma tuberous sclerosis fetal therapy |
| url | http://ogscience.org/upload/pdf/ogs-62-280.pdf |
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