A Personalized Approach to the Treatment of Primary Open-Angle Glaucoma
Aim — to study of gene polymorphisms affecting the effectiveness of timolol treatment of primary open-angle glaucoma.Patients and Methods. The study included 39 Russian patients (29 women and 10 men) aged 53 to 89 years old with a diagnosis of primary open-angle glaucoma (POAG). Intraocular pressure...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2021-10-01
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| Series: | Oftalʹmologiâ |
| Subjects: | |
| Online Access: | https://www.ophthalmojournal.com/opht/article/view/1612 |
| _version_ | 1797875401299591168 |
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| author | A. L. Onishchenko N. V. Maltseva A. Sh. Smirnova O. M. Kazantseva S. I. Makogon |
| author_facet | A. L. Onishchenko N. V. Maltseva A. Sh. Smirnova O. M. Kazantseva S. I. Makogon |
| author_sort | A. L. Onishchenko |
| collection | DOAJ |
| description | Aim — to study of gene polymorphisms affecting the effectiveness of timolol treatment of primary open-angle glaucoma.Patients and Methods. The study included 39 Russian patients (29 women and 10 men) aged 53 to 89 years old with a diagnosis of primary open-angle glaucoma (POAG). Intraocular pressure (IOP) was measured before the start of therapy and after 2 weeks during treatment. Сoefficient of decrease in IOP was calculated in percentage of its initial level (∆D). Patients were genotyped according to the polymorphic loci MMP1-160insG, MMP12A-82G, TIMP1C536T, ADRB1Arg389Gly, ADRB1Ser49Gly, NAT2Lys268Arg, GSTP1Ile105Val using the corresponding SNP-express reagent kits (NPF Lytech, Moscow).Results. No effect of MMP12A-82G, TIMP1C536T, ADRB1Arg389Gly, NAT2Lys268Arg polymorphisms on efficiency of reduction of IOP under action of thymolol in “best” eyes was revealed. The carriage of a homozygous genotype GSTP1Ile105Ile resulted in the best ophthalmic hypotensive effect of a timolol (∆D ≥ 20 %), which probability was 5.63 times higher in comparison with ∆D < 20 %. In the “worst” eyes, the association of carriage of a combination of wild genotypes GSTP1Ile105Ile×NAT2Lys268Lys with the best response of patients to timolol was revealed. The ophthalmic hypotensive effect of 10 ≤ ∆D < 20 % in such carriers was more than 11 times more likely than ∆D < 10 %.Conclusion. The carriage of the wild genotype GSTP1Ile105Ile determines the best ophthalmic hypotensive effect of timolol and can be a prognostic marker for the effective treatment of patients with POAG. The combination of wild genotypes GSTP1Ile105Ile×NAT2Lys268Lys can contribute to the better therapeutic effect of timolol, and mutant ones can prevent it. |
| first_indexed | 2024-04-10T01:47:04Z |
| format | Article |
| id | doaj.art-bc6b3f1a053547fbae6399b33290cd7c |
| institution | Directory Open Access Journal |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| last_indexed | 2024-04-10T01:47:04Z |
| publishDate | 2021-10-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj.art-bc6b3f1a053547fbae6399b33290cd7c2023-03-13T09:08:42ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452021-10-0118354655110.18008/1816-5095-2021-3-546-551792A Personalized Approach to the Treatment of Primary Open-Angle GlaucomaA. L. Onishchenko0N. V. Maltseva1A. Sh. Smirnova2O. M. Kazantseva3S. I. Makogon4Новокузнецкий государственный институт усовершенствования врачей — филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской ФедерацииНовокузнецкий государственный институт усовершенствования врачей — филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской ФедерацииНовокузнецкий государственный институт усовершенствования врачей — филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской ФедерацииНовокузнецкий государственный институт усовершенствования врачей — филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской ФедерацииНовокузнецкий государственный институт усовершенствования врачей — филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской ФедерацииAim — to study of gene polymorphisms affecting the effectiveness of timolol treatment of primary open-angle glaucoma.Patients and Methods. The study included 39 Russian patients (29 women and 10 men) aged 53 to 89 years old with a diagnosis of primary open-angle glaucoma (POAG). Intraocular pressure (IOP) was measured before the start of therapy and after 2 weeks during treatment. Сoefficient of decrease in IOP was calculated in percentage of its initial level (∆D). Patients were genotyped according to the polymorphic loci MMP1-160insG, MMP12A-82G, TIMP1C536T, ADRB1Arg389Gly, ADRB1Ser49Gly, NAT2Lys268Arg, GSTP1Ile105Val using the corresponding SNP-express reagent kits (NPF Lytech, Moscow).Results. No effect of MMP12A-82G, TIMP1C536T, ADRB1Arg389Gly, NAT2Lys268Arg polymorphisms on efficiency of reduction of IOP under action of thymolol in “best” eyes was revealed. The carriage of a homozygous genotype GSTP1Ile105Ile resulted in the best ophthalmic hypotensive effect of a timolol (∆D ≥ 20 %), which probability was 5.63 times higher in comparison with ∆D < 20 %. In the “worst” eyes, the association of carriage of a combination of wild genotypes GSTP1Ile105Ile×NAT2Lys268Lys with the best response of patients to timolol was revealed. The ophthalmic hypotensive effect of 10 ≤ ∆D < 20 % in such carriers was more than 11 times more likely than ∆D < 10 %.Conclusion. The carriage of the wild genotype GSTP1Ile105Ile determines the best ophthalmic hypotensive effect of timolol and can be a prognostic marker for the effective treatment of patients with POAG. The combination of wild genotypes GSTP1Ile105Ile×NAT2Lys268Lys can contribute to the better therapeutic effect of timolol, and mutant ones can prevent it.https://www.ophthalmojournal.com/opht/article/view/1612терапия глаукомытимололгенполиморфизмn-ацетилтрансфераза 2глутатион-s-трансфераза р1офтальмогипотензивный эффект |
| spellingShingle | A. L. Onishchenko N. V. Maltseva A. Sh. Smirnova O. M. Kazantseva S. I. Makogon A Personalized Approach to the Treatment of Primary Open-Angle Glaucoma Oftalʹmologiâ терапия глаукомы тимолол ген полиморфизм n-ацетилтрансфераза 2 глутатион-s-трансфераза р1 офтальмогипотензивный эффект |
| title | A Personalized Approach to the Treatment of Primary Open-Angle Glaucoma |
| title_full | A Personalized Approach to the Treatment of Primary Open-Angle Glaucoma |
| title_fullStr | A Personalized Approach to the Treatment of Primary Open-Angle Glaucoma |
| title_full_unstemmed | A Personalized Approach to the Treatment of Primary Open-Angle Glaucoma |
| title_short | A Personalized Approach to the Treatment of Primary Open-Angle Glaucoma |
| title_sort | personalized approach to the treatment of primary open angle glaucoma |
| topic | терапия глаукомы тимолол ген полиморфизм n-ацетилтрансфераза 2 глутатион-s-трансфераза р1 офтальмогипотензивный эффект |
| url | https://www.ophthalmojournal.com/opht/article/view/1612 |
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