L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice.
Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of L-serine supplementation on autoimmune diabet...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5854405?pdf=render |
| _version_ | 1819050989190119424 |
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| author | Laurits J Holm Martin Haupt-Jorgensen Jesper Larsen Jano D Giacobini Mesut Bilgin Karsten Buschard |
| author_facet | Laurits J Holm Martin Haupt-Jorgensen Jesper Larsen Jano D Giacobini Mesut Bilgin Karsten Buschard |
| author_sort | Laurits J Holm |
| collection | DOAJ |
| description | Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of L-serine supplementation on autoimmune diabetes development and blood glucose homeostasis in female NOD mice. We found that continuous supplementation of L-serine reduces diabetes incidence and insulitis score. In addition, L-serine treated mice had an improved glucose tolerance test, reduced HOMA-IR, and reduced blood glucose levels. L-serine led to a small reduction in body weight accompanied by reduced food and water intake. L-serine had no effect on pancreatic sphingolipids as measured by mass spectrometry. The data thus suggests that L-serine could be used as a therapeutic supplement in the treatment of Type 1 Diabetes and to improve blood glucose homeostasis. |
| first_indexed | 2024-12-21T11:56:48Z |
| format | Article |
| id | doaj.art-bc6b7c684378410db0b95b3b96ab786f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T11:56:48Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-bc6b7c684378410db0b95b3b96ab786f2022-12-21T19:04:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01133e019441410.1371/journal.pone.0194414L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice.Laurits J HolmMartin Haupt-JorgensenJesper LarsenJano D GiacobiniMesut BilginKarsten BuschardSphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of L-serine supplementation on autoimmune diabetes development and blood glucose homeostasis in female NOD mice. We found that continuous supplementation of L-serine reduces diabetes incidence and insulitis score. In addition, L-serine treated mice had an improved glucose tolerance test, reduced HOMA-IR, and reduced blood glucose levels. L-serine led to a small reduction in body weight accompanied by reduced food and water intake. L-serine had no effect on pancreatic sphingolipids as measured by mass spectrometry. The data thus suggests that L-serine could be used as a therapeutic supplement in the treatment of Type 1 Diabetes and to improve blood glucose homeostasis.http://europepmc.org/articles/PMC5854405?pdf=render |
| spellingShingle | Laurits J Holm Martin Haupt-Jorgensen Jesper Larsen Jano D Giacobini Mesut Bilgin Karsten Buschard L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice. PLoS ONE |
| title | L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice. |
| title_full | L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice. |
| title_fullStr | L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice. |
| title_full_unstemmed | L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice. |
| title_short | L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice. |
| title_sort | l serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in nod mice |
| url | http://europepmc.org/articles/PMC5854405?pdf=render |
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