L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice.

L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice.

Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of L-serine supplementation on autoimmune diabet...

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Bibliographic Details
Main Authors: Laurits J Holm, Martin Haupt-Jorgensen, Jesper Larsen, Jano D Giacobini, Mesut Bilgin, Karsten Buschard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5854405?pdf=render

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