The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis
Abstract Background The aim of this systematic review and meta-analysis was to summarize the association of obstructive sleep apnea (OSA) with renal outcome. Methods Our study followed the PRISMA guidelines. Two independent reviewers searched for relevant articles in the databases of Pubmed, the Web...
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-017-0731-2 |
| _version_ | 1819063983046393856 |
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| author | Der-Wei Hwu Kun-Der Lin Kun-Chen Lin Yau-Jiunn Lee Yu-Hung Chang |
| author_facet | Der-Wei Hwu Kun-Der Lin Kun-Chen Lin Yau-Jiunn Lee Yu-Hung Chang |
| author_sort | Der-Wei Hwu |
| collection | DOAJ |
| description | Abstract Background The aim of this systematic review and meta-analysis was to summarize the association of obstructive sleep apnea (OSA) with renal outcome. Methods Our study followed the PRISMA guidelines. Two independent reviewers searched for relevant articles in the databases of Pubmed, the Web of Science and CENTRAL, and conducted study selection and quality assessment. A random-effect model was used to estimate the effects. Results A total of 1240 articles were initially identified (Pubmed = 568, Web of Science = 640, CENTRAL = 32). After removal of duplicate articles (n = 415) and irrelevant articles (n = 788), 37 were selected for full-text review, and 18 were finally included in the analysis. Overall, patients diagnosed with OSA were found to have a higher odds ratio (OR) of a poorer renal outcome, with a pooled OR of 1.77 (95% C.I.: 1.37–2.29). The significant association between OSA and a poorer renal outcome was not affected by the medical condition of diabetes mellitus (DM). In addition, we found that OSA was consistently associated with higher albuminuria/proteinuria and a lower estimated glomerular filtration rate (eGFR), with a pooled OR of 1.84 (95% C.I.: 1.24–2.73) and 1.60 (95% C.I.: 1.19–2.16), respectively. A greater OSA severity was also found to be related to a higher OR, with a mild group OR of 1.45 (95% C.I.: 1.19–1.77) and a moderate and severe group OR of 2.39 (95% C.I.: 1.96–2.90). Conclusions Our study demonstrated that OSA is significantly associated with poorer renal function. |
| first_indexed | 2024-12-21T15:23:20Z |
| format | Article |
| id | doaj.art-bc6c254c42714046a155f6d1a3c61b06 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-21T15:23:20Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-bc6c254c42714046a155f6d1a3c61b062022-12-21T18:58:59ZengBMCBMC Nephrology1471-23692017-10-0118111010.1186/s12882-017-0731-2The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysisDer-Wei Hwu0Kun-Der Lin1Kun-Chen Lin2Yau-Jiunn Lee3Yu-Hung Chang4Department of Internal Medicine, Lee’s Endocrinology ClinicDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical UniversityDepartment of Internal Medicine, Lee’s Endocrinology ClinicDepartment of Internal Medicine, Lee’s Endocrinology ClinicDepartment of Internal Medicine, Lee’s Endocrinology ClinicAbstract Background The aim of this systematic review and meta-analysis was to summarize the association of obstructive sleep apnea (OSA) with renal outcome. Methods Our study followed the PRISMA guidelines. Two independent reviewers searched for relevant articles in the databases of Pubmed, the Web of Science and CENTRAL, and conducted study selection and quality assessment. A random-effect model was used to estimate the effects. Results A total of 1240 articles were initially identified (Pubmed = 568, Web of Science = 640, CENTRAL = 32). After removal of duplicate articles (n = 415) and irrelevant articles (n = 788), 37 were selected for full-text review, and 18 were finally included in the analysis. Overall, patients diagnosed with OSA were found to have a higher odds ratio (OR) of a poorer renal outcome, with a pooled OR of 1.77 (95% C.I.: 1.37–2.29). The significant association between OSA and a poorer renal outcome was not affected by the medical condition of diabetes mellitus (DM). In addition, we found that OSA was consistently associated with higher albuminuria/proteinuria and a lower estimated glomerular filtration rate (eGFR), with a pooled OR of 1.84 (95% C.I.: 1.24–2.73) and 1.60 (95% C.I.: 1.19–2.16), respectively. A greater OSA severity was also found to be related to a higher OR, with a mild group OR of 1.45 (95% C.I.: 1.19–1.77) and a moderate and severe group OR of 2.39 (95% C.I.: 1.96–2.90). Conclusions Our study demonstrated that OSA is significantly associated with poorer renal function.http://link.springer.com/article/10.1186/s12882-017-0731-2Obstructive sleep apneaChronic kidney diseaseDiabetesProteinuriaAlbuminuria |
| spellingShingle | Der-Wei Hwu Kun-Der Lin Kun-Chen Lin Yau-Jiunn Lee Yu-Hung Chang The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis BMC Nephrology Obstructive sleep apnea Chronic kidney disease Diabetes Proteinuria Albuminuria |
| title | The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis |
| title_full | The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis |
| title_fullStr | The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis |
| title_full_unstemmed | The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis |
| title_short | The association of obstructive sleep apnea and renal outcomes—a systematic review and meta-analysis |
| title_sort | association of obstructive sleep apnea and renal outcomes a systematic review and meta analysis |
| topic | Obstructive sleep apnea Chronic kidney disease Diabetes Proteinuria Albuminuria |
| url | http://link.springer.com/article/10.1186/s12882-017-0731-2 |
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