Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein
<p>Abstract</p> <p>Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. We are searching for low molecular weight compounds to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2008-12-01
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| Series: | BMC Neuroscience |
| _version_ | 1818689836498812928 |
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| author | Mandelkow Eckhard Panneerselvam Saravanan Marx Alexander Timm Thomas Mandelkow Eva-Maria |
| author_facet | Mandelkow Eckhard Panneerselvam Saravanan Marx Alexander Timm Thomas Mandelkow Eva-Maria |
| author_sort | Mandelkow Eckhard |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. We are searching for low molecular weight compounds to interfere with the activity of MARK and its pathways. Here we summarize structural features of MARK and cellular pathways of regulation.</p> |
| first_indexed | 2024-12-17T12:16:26Z |
| format | Article |
| id | doaj.art-bc6cc4dbd4d249288b82f5fda8ea1ff3 |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-12-17T12:16:26Z |
| publishDate | 2008-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-bc6cc4dbd4d249288b82f5fda8ea1ff32022-12-21T21:49:09ZengBMCBMC Neuroscience1471-22022008-12-019Suppl 2S910.1186/1471-2202-9-S2-S9Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau proteinMandelkow EckhardPanneerselvam SaravananMarx AlexanderTimm ThomasMandelkow Eva-Maria<p>Abstract</p> <p>Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. We are searching for low molecular weight compounds to interfere with the activity of MARK and its pathways. Here we summarize structural features of MARK and cellular pathways of regulation.</p> |
| spellingShingle | Mandelkow Eckhard Panneerselvam Saravanan Marx Alexander Timm Thomas Mandelkow Eva-Maria Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein BMC Neuroscience |
| title | Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein |
| title_full | Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein |
| title_fullStr | Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein |
| title_full_unstemmed | Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein |
| title_short | Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein |
| title_sort | structure and regulation of mark a kinase involved in abnormal phosphorylation of tau protein |
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