Hodgkin's disease and renal paraneoplastic syndromes in childhood
The purpose of this study was to investigate children followed as having both Hodgkin's disease (HD) and nephropathy and discuss the factors which might play roles in the pathogenesis of this association by reviewing the pertinent literature. Our experience among 661 children with HD rev...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2000-04-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3114 |
| _version_ | 1826543688675753984 |
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| author | M Büyükpamukçu V Hazar K Tinaztepe A Bakkaloğlu C Akyüz T Kutluk |
| author_facet | M Büyükpamukçu V Hazar K Tinaztepe A Bakkaloğlu C Akyüz T Kutluk |
| author_sort | M Büyükpamukçu |
| collection | DOAJ |
| description |
The purpose of this study was to investigate children followed as having both Hodgkin's disease (HD) and nephropathy and discuss the factors which might play roles in the pathogenesis of this association by reviewing the pertinent literature. Our experience among 661 children with HD revealed ten cases (1.5%) with nephropathy; eight of these were biopsy proven. Tissue diagnoses were amyloidosis (AA type) in four cases, and membranoproliferative glomerulonephritis and minimal change glomerulopathy in two cases each. Sex distribution was equal. There was a predominance of the mixed cellular (MC) histologic type in our patients with HD. Nephropathy was shown to antedate the diagnosis of HD in two cases and to herald a relapse in one. In brief, the development of a nephropathy in a patient with HD can be considered as a paraneoplastic phenomenon. Renal amyloidosis may already be present at the time of diagnosis of HD and must be kept in mind as a cause of proteinuria due to preexisting nephropathy. Developing renal paraneoplastic syndrome, even in early-staged HD, in children, may be a poor prognostic factor.
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| first_indexed | 2025-03-14T04:50:03Z |
| format | Article |
| id | doaj.art-bc6d197d6ac64954a9ef63b6fe5ecf89 |
| institution | Directory Open Access Journal |
| issn | 0041-4301 2791-6421 |
| language | English |
| last_indexed | 2025-03-14T04:50:03Z |
| publishDate | 2000-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj.art-bc6d197d6ac64954a9ef63b6fe5ecf892025-03-07T19:43:52ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212000-04-01422Hodgkin's disease and renal paraneoplastic syndromes in childhoodM Büyükpamukçu0V HazarK TinaztepeA BakkaloğluC AkyüzT KutlukDepartment of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. The purpose of this study was to investigate children followed as having both Hodgkin's disease (HD) and nephropathy and discuss the factors which might play roles in the pathogenesis of this association by reviewing the pertinent literature. Our experience among 661 children with HD revealed ten cases (1.5%) with nephropathy; eight of these were biopsy proven. Tissue diagnoses were amyloidosis (AA type) in four cases, and membranoproliferative glomerulonephritis and minimal change glomerulopathy in two cases each. Sex distribution was equal. There was a predominance of the mixed cellular (MC) histologic type in our patients with HD. Nephropathy was shown to antedate the diagnosis of HD in two cases and to herald a relapse in one. In brief, the development of a nephropathy in a patient with HD can be considered as a paraneoplastic phenomenon. Renal amyloidosis may already be present at the time of diagnosis of HD and must be kept in mind as a cause of proteinuria due to preexisting nephropathy. Developing renal paraneoplastic syndrome, even in early-staged HD, in children, may be a poor prognostic factor. https://turkjpediatr.org/article/view/3114 |
| spellingShingle | M Büyükpamukçu V Hazar K Tinaztepe A Bakkaloğlu C Akyüz T Kutluk Hodgkin's disease and renal paraneoplastic syndromes in childhood The Turkish Journal of Pediatrics |
| title | Hodgkin's disease and renal paraneoplastic syndromes in childhood |
| title_full | Hodgkin's disease and renal paraneoplastic syndromes in childhood |
| title_fullStr | Hodgkin's disease and renal paraneoplastic syndromes in childhood |
| title_full_unstemmed | Hodgkin's disease and renal paraneoplastic syndromes in childhood |
| title_short | Hodgkin's disease and renal paraneoplastic syndromes in childhood |
| title_sort | hodgkin s disease and renal paraneoplastic syndromes in childhood |
| url | https://turkjpediatr.org/article/view/3114 |
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