The role of occupational factors in the development and course of respiratory sarcoidosis
Aim. The aim of the study was to study the frequency of occurrence of exposure to harmful occupational factors in patients with sarcoidosis of the respiratory organs, depending on the course of the disease. Materials and methods. An open prospective study included 121 patients with sarcoidosis of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2021-03-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/64950/47805 |
| _version_ | 1819130303760826368 |
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| author | Inna A. Palchikovа Olga A. Denisovа Galina M. Chernyavskaya Tatiana P. Kalacheva Igor L. Purlik Elena V. Bolotova |
| author_facet | Inna A. Palchikovа Olga A. Denisovа Galina M. Chernyavskaya Tatiana P. Kalacheva Igor L. Purlik Elena V. Bolotova |
| author_sort | Inna A. Palchikovа |
| collection | DOAJ |
| description | Aim. The aim of the study was to study the frequency of occurrence of exposure to harmful occupational factors in patients with sarcoidosis of the respiratory organs, depending on the course of the disease.
Materials and methods. An open prospective study included 121 patients with sarcoidosis of the respiratory system from the age of 21 to 66 years, from 20072019. The diagnosis was histologically confirmed in all patients. Patients underwent a set of laboratory and instrumental examinations, studied profane history. The presence of a history of contact with harmful and dangerous production factors was clarified. To determine the effect of a harmful production factor on the course of sarcoidosis, patients were divided into 2 clinical groups: the first group consisted of 85 (70.2%) patients with a favorable course of the disease, the second group included 36 (29.8%) patients with an unfavorable course sarcoidosis (standardization coefficient between groups 2.4:1).
Results and discussion. Among the examined patients of working age prevailed (87%). Patient groups were comparable by age, but statistically differed by gender (chi2=9.75, p=0.0018). Frequency analysis of the occurrence of harmful occupational factors in sarcoidosis of the respiratory organs showed that the most frequently encountered factors in all the studied groups were contact with chemical hazards.
Conclusion. The presence of contact with harmful production factors increases the risk of an unfavorable course of sarcoidosis by more than 2 times. |
| first_indexed | 2024-12-22T08:57:28Z |
| format | Article |
| id | doaj.art-bc6f45062cee479cbcf510ee945d54b5 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-22T08:57:28Z |
| publishDate | 2021-03-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-bc6f45062cee479cbcf510ee945d54b52022-12-21T18:31:48Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422021-03-0193326026410.26442/00403660.2021.03.20063759385The role of occupational factors in the development and course of respiratory sarcoidosisInna A. Palchikovа0https://orcid.org/0000-0003-4968-1110Olga A. Denisovа1https://orcid.org/0000-0003-1652-9622Galina M. Chernyavskaya2https://orcid.org/0000-0003-0105-2307Tatiana P. Kalacheva3https://orcid.org/0000-0002-4292-7723Igor L. Purlik4https://orcid.org/0000-0003-3757-0173Elena V. Bolotova5https://orcid.org/0000-0001-6257-354XTomsk Regional Clinical HospitalSiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversityKuban State Medical UniversityAim. The aim of the study was to study the frequency of occurrence of exposure to harmful occupational factors in patients with sarcoidosis of the respiratory organs, depending on the course of the disease. Materials and methods. An open prospective study included 121 patients with sarcoidosis of the respiratory system from the age of 21 to 66 years, from 20072019. The diagnosis was histologically confirmed in all patients. Patients underwent a set of laboratory and instrumental examinations, studied profane history. The presence of a history of contact with harmful and dangerous production factors was clarified. To determine the effect of a harmful production factor on the course of sarcoidosis, patients were divided into 2 clinical groups: the first group consisted of 85 (70.2%) patients with a favorable course of the disease, the second group included 36 (29.8%) patients with an unfavorable course sarcoidosis (standardization coefficient between groups 2.4:1). Results and discussion. Among the examined patients of working age prevailed (87%). Patient groups were comparable by age, but statistically differed by gender (chi2=9.75, p=0.0018). Frequency analysis of the occurrence of harmful occupational factors in sarcoidosis of the respiratory organs showed that the most frequently encountered factors in all the studied groups were contact with chemical hazards. Conclusion. The presence of contact with harmful production factors increases the risk of an unfavorable course of sarcoidosis by more than 2 times.https://ter-arkhiv.ru/0040-3660/article/viewFile/64950/47805sarcoidosisharmful professional factorsvariants of the course of sarcoidosis the respiratory organs |
| spellingShingle | Inna A. Palchikovа Olga A. Denisovа Galina M. Chernyavskaya Tatiana P. Kalacheva Igor L. Purlik Elena V. Bolotova The role of occupational factors in the development and course of respiratory sarcoidosis Терапевтический архив sarcoidosis harmful professional factors variants of the course of sarcoidosis the respiratory organs |
| title | The role of occupational factors in the development and course of respiratory sarcoidosis |
| title_full | The role of occupational factors in the development and course of respiratory sarcoidosis |
| title_fullStr | The role of occupational factors in the development and course of respiratory sarcoidosis |
| title_full_unstemmed | The role of occupational factors in the development and course of respiratory sarcoidosis |
| title_short | The role of occupational factors in the development and course of respiratory sarcoidosis |
| title_sort | role of occupational factors in the development and course of respiratory sarcoidosis |
| topic | sarcoidosis harmful professional factors variants of the course of sarcoidosis the respiratory organs |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/64950/47805 |
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