Clinical Case of Sarcoidosis as a Rare Cause of Lymphadenopathy in Preschool Child
Background. Assignment of causes of generalized lymphadenopathy causes as a symptom of various diseases is still challenging. In case of no infectious causes, the morphological study is necessary also to exclude sarcoidosis, rare for young children immunemediated systemic disease with intermediate p...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2022-05-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/2907 |
| _version_ | 1797702236593192960 |
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| author | Elena Y. Khorosheva Elena B. Khramova Natalya E. Gorohova Natalya A. Mashkina Nikolay V. Kozlov Ksenia P. Kuzmicheva |
| author_facet | Elena Y. Khorosheva Elena B. Khramova Natalya E. Gorohova Natalya A. Mashkina Nikolay V. Kozlov Ksenia P. Kuzmicheva |
| author_sort | Elena Y. Khorosheva |
| collection | DOAJ |
| description | Background. Assignment of causes of generalized lymphadenopathy causes as a symptom of various diseases is still challenging. In case of no infectious causes, the morphological study is necessary also to exclude sarcoidosis, rare for young children immunemediated systemic disease with intermediate prognosis.Clinical case description. 4 years girl was diagnosed sarcoidosis with typical lesions of intrathoracic lymph nodes and lungs along with signs of generalized lymphadenopathy. Molecular genetic testing has revealed pathogenic variant in the TNFRSF13B gene that was previously described in adult patients with general variable immunodeficiency and pulmonary sarcoidosis. Catamnestic follow-up data on this patient are presented for 3 years. There were no relapses without immunosuppressive therapy.Conclusion. Sarcoidosis was described as the cause of generalized lymphadenopathy in preschool child. Following the federal guidelines has helped to adjust diagnosis tactics, to establish diagnosis, and to choose treatment. |
| first_indexed | 2024-03-12T04:48:16Z |
| format | Article |
| id | doaj.art-bc73223f702d46298bd38df9659ed9c2 |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T04:48:16Z |
| publishDate | 2022-05-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-bc73223f702d46298bd38df9659ed9c22023-09-03T09:26:48Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352022-05-0121211812410.15690/vsp.v21i2.23932031Clinical Case of Sarcoidosis as a Rare Cause of Lymphadenopathy in Preschool ChildElena Y. Khorosheva0Elena B. Khramova1Natalya E. Gorohova2Natalya A. Mashkina3Nikolay V. Kozlov4Ksenia P. Kuzmicheva5Тюменский государственный медицинский университет; Областная клиническая больница № 1Тюменский государственный медицинский университетОбластная клиническая больница № 1Областная клиническая больница № 1Областной клинический фтизиопульмонологический центрТюменский государственный медицинский университет; Областная клиническая больница № 1Background. Assignment of causes of generalized lymphadenopathy causes as a symptom of various diseases is still challenging. In case of no infectious causes, the morphological study is necessary also to exclude sarcoidosis, rare for young children immunemediated systemic disease with intermediate prognosis.Clinical case description. 4 years girl was diagnosed sarcoidosis with typical lesions of intrathoracic lymph nodes and lungs along with signs of generalized lymphadenopathy. Molecular genetic testing has revealed pathogenic variant in the TNFRSF13B gene that was previously described in adult patients with general variable immunodeficiency and pulmonary sarcoidosis. Catamnestic follow-up data on this patient are presented for 3 years. There were no relapses without immunosuppressive therapy.Conclusion. Sarcoidosis was described as the cause of generalized lymphadenopathy in preschool child. Following the federal guidelines has helped to adjust diagnosis tactics, to establish diagnosis, and to choose treatment.https://vsp.spr-journal.ru/jour/article/view/2907детиклинический случайлимфаденопатиясаркоидоз |
| spellingShingle | Elena Y. Khorosheva Elena B. Khramova Natalya E. Gorohova Natalya A. Mashkina Nikolay V. Kozlov Ksenia P. Kuzmicheva Clinical Case of Sarcoidosis as a Rare Cause of Lymphadenopathy in Preschool Child Вопросы современной педиатрии дети клинический случай лимфаденопатия саркоидоз |
| title | Clinical Case of Sarcoidosis as a Rare Cause of Lymphadenopathy in Preschool Child |
| title_full | Clinical Case of Sarcoidosis as a Rare Cause of Lymphadenopathy in Preschool Child |
| title_fullStr | Clinical Case of Sarcoidosis as a Rare Cause of Lymphadenopathy in Preschool Child |
| title_full_unstemmed | Clinical Case of Sarcoidosis as a Rare Cause of Lymphadenopathy in Preschool Child |
| title_short | Clinical Case of Sarcoidosis as a Rare Cause of Lymphadenopathy in Preschool Child |
| title_sort | clinical case of sarcoidosis as a rare cause of lymphadenopathy in preschool child |
| topic | дети клинический случай лимфаденопатия саркоидоз |
| url | https://vsp.spr-journal.ru/jour/article/view/2907 |
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