Serum IL-1β levels and its influencing factors in patients with postherpetic neuralgia
Objective: To investigate the serum IL-1β levels and its influencing factors in patients with postherpetic neuralgia (PHN). Methods: A total of 145 patients with PHN and 40 healthy controls were enrolled in our hospital from January 2014 to January 2019. Enzyme-linked immunosorbent assay (ELISA) was...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2019-10-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/CN/abstract/abstract1748.shtml |
| _version_ | 1797990528084606976 |
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| author | Xing LI Bao-chao ZHANG Ben NIU Wei ZHAO |
| author_facet | Xing LI Bao-chao ZHANG Ben NIU Wei ZHAO |
| author_sort | Xing LI |
| collection | DOAJ |
| description | Objective: To investigate the serum IL-1β levels and its influencing factors in patients with postherpetic neuralgia (PHN). Methods: A total of 145 patients with PHN and 40 healthy controls were enrolled in our hospital from January 2014 to January 2019. Enzyme-linked immunosorbent assay (ELISA) was used to detect serum IL-1β levels. Single factor and logistic regression analyses were used to determine the influencing factors of serum IL-1β levels in patients with PHN. Pearson correlation analysis was used to analyze the correlation between serum IL-1β levels and VAS scores. Results: The serum IL-1β levels in PHN group were significantly higher than that in the controls [ (20.18±5.63) pg/mL vs (10.36±1.19) pg/mL, t=10.94, P<0.01)]. Multivariate logistic analysis showed that age (OR=3.541) and VAS scores of acute stage (OR=6.237) in PHN patients were related to the serum IL-1β levels. There was a significant positive correlation between serum IL-1β levels and VAS scores, with the correlation coefficient of r=0.64(P<0.05). Conclusions: The serum IL-1β levels in patients with PHN increase significantly, and IL-1β may be involved in the pathogenesis of PHN. IL-1β can reflect the severity of pain in patients with herpes zoster in acute stage. |
| first_indexed | 2024-04-11T08:37:01Z |
| format | Article |
| id | doaj.art-bc736c0467674a5989445a7e2216aa28 |
| institution | Directory Open Access Journal |
| issn | 1674-8468 |
| language | zho |
| last_indexed | 2024-04-11T08:37:01Z |
| publishDate | 2019-10-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj.art-bc736c0467674a5989445a7e2216aa282022-12-22T04:34:18Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682019-10-0126527127510.3969/j.issn.1674-8468.2019.05.002Serum IL-1β levels and its influencing factors in patients with postherpetic neuralgiaXing LIBao-chao ZHANGBen NIUWei ZHAOObjective: To investigate the serum IL-1β levels and its influencing factors in patients with postherpetic neuralgia (PHN). Methods: A total of 145 patients with PHN and 40 healthy controls were enrolled in our hospital from January 2014 to January 2019. Enzyme-linked immunosorbent assay (ELISA) was used to detect serum IL-1β levels. Single factor and logistic regression analyses were used to determine the influencing factors of serum IL-1β levels in patients with PHN. Pearson correlation analysis was used to analyze the correlation between serum IL-1β levels and VAS scores. Results: The serum IL-1β levels in PHN group were significantly higher than that in the controls [ (20.18±5.63) pg/mL vs (10.36±1.19) pg/mL, t=10.94, P<0.01)]. Multivariate logistic analysis showed that age (OR=3.541) and VAS scores of acute stage (OR=6.237) in PHN patients were related to the serum IL-1β levels. There was a significant positive correlation between serum IL-1β levels and VAS scores, with the correlation coefficient of r=0.64(P<0.05). Conclusions: The serum IL-1β levels in patients with PHN increase significantly, and IL-1β may be involved in the pathogenesis of PHN. IL-1β can reflect the severity of pain in patients with herpes zoster in acute stage.http://pfxbzlx.gdvdc.com/CN/abstract/abstract1748.shtmlherpes zosterpostherpetic neuralgiail-1βmultivariate analysis |
| spellingShingle | Xing LI Bao-chao ZHANG Ben NIU Wei ZHAO Serum IL-1β levels and its influencing factors in patients with postherpetic neuralgia Pifu-xingbing zhenliaoxue zazhi herpes zoster postherpetic neuralgia il-1β multivariate analysis |
| title | Serum IL-1β levels and its influencing factors in patients with postherpetic neuralgia |
| title_full | Serum IL-1β levels and its influencing factors in patients with postherpetic neuralgia |
| title_fullStr | Serum IL-1β levels and its influencing factors in patients with postherpetic neuralgia |
| title_full_unstemmed | Serum IL-1β levels and its influencing factors in patients with postherpetic neuralgia |
| title_short | Serum IL-1β levels and its influencing factors in patients with postherpetic neuralgia |
| title_sort | serum il 1β levels and its influencing factors in patients with postherpetic neuralgia |
| topic | herpes zoster postherpetic neuralgia il-1β multivariate analysis |
| url | http://pfxbzlx.gdvdc.com/CN/abstract/abstract1748.shtml |
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