Improvement of Transmembrane Transport Mechanism Study of Imperatorin on P-Glycoprotein-Mediated Drug Transport

Improvement of Transmembrane Transport Mechanism Study of Imperatorin on P-Glycoprotein-Mediated Drug Transport

P-glycoprotein (P-gp) affects the transport of many drugs; including puerarin and vincristine. Our previous study demonstrated that imperatorin increased the intestinal absorption of puerarin and vincristine by inhibiting P-gp-mediated drug efflux. However; the underlying mechanism was not known. Th...

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Bibliographic Details
Main Authors: Zheng-Gen Liao, Tao Tang, Xue-Jing Guan, Wei Dong, Jing Zhang, Guo-Wei Zhao, Ming Yang, Xin-Li Liang
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molecules
Subjects:
imperatorin
P-glycoprotein (P-gp)
transmembrane transport
mechanism
Online Access:http://www.mdpi.com/1420-3049/21/12/1606

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