Temporary Shutdown of ERK1/2 Phosphorylation Is Associated With Activation of Adaptive Immune Cell Responses and Disease Progression During Leishmania amazonensis Infection in BALB/c Mice

Temporary Shutdown of ERK1/2 Phosphorylation Is Associated With Activation of Adaptive Immune Cell Responses and Disease Progression During Leishmania amazonensis Infection in BALB/c Mice

Leishmania spp. infection outcomes are dependent on both host and parasite factors. Manipulation of host signaling pathways involved in the generation of immune responses is thought to be one of the most common mechanisms used by parasites for persistence within the host. Considering the diversity o...

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Bibliographic Details
Main Authors: Leandro G. Oliveira, Míriam C. Souza-Testasicca, Tiago Nery Queiroga Ricotta, Juliana P. Vago, Liliane M. dos Santos, Frederico Crepaldi, Kátia M. Lima, Celso Queiroz-Junior, Lirlândia P. Sousa, Ana Paula Fernandes
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
L. amazonensis
kinetics of ERK1/2 activation
inflammation
leishmaniasis infection
L. braziliensis
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.762080/full

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