ABT-263 Reduces Hypertrophic Scars by Targeting Apoptosis of Myofibroblasts

ABT-263 Reduces Hypertrophic Scars by Targeting Apoptosis of Myofibroblasts

Background: Inhibiting proliferation and inducing apoptosis of myofibroblasts is becoming one of the promising and effective ways to treat hypertrophic scar. ABT-263, as an orally bioavailable BCL-2 family inhibitor, has showed great antitumor characteristics by targeting tumor cell apoptosis. The o...

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Bibliographic Details
Main Authors: Xiaolan Yang, Yongqiang Xiao, Chenjian Zhong, Futing Shu, Shichu Xiao, Yongjun Zheng, Zhaofan Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
ABT-263
hypertrophic scar
apoptosis
myofibroblast
skin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.615505/full

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