Cyclic Hypoxia Induces Transcriptomic Changes in Mast Cells Leading to a Hyperresponsive Phenotype after FcεRI Cross-Linking

Cyclic Hypoxia Induces Transcriptomic Changes in Mast Cells Leading to a Hyperresponsive Phenotype after FcεRI Cross-Linking

Mast cells (MCs) play important roles in tumor development, executing pro- or antitumoral functions depending on tumor type and tumor microenvironment (TME) conditions. Cyclic hypoxia (cyH) is a common feature of TME since tumor blood vessels fail to provide a continuous supply of oxygen to the tumo...

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Bibliographic Details
Main Authors: Deisy Segura-Villalobos, Monica Lamas, Claudia González-Espinosa
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
mast cells
cyclic hypoxia
hyperresponsive phenotype
degranulation
cancer
tumor microenvironment
Online Access:https://www.mdpi.com/2073-4409/11/14/2239

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