Mutant-Allele Tumor Heterogeneity, a Favorable Biomarker to Assess Intra-Tumor Heterogeneity, in Advanced Lung Adenocarcinoma

Mutant-Allele Tumor Heterogeneity, a Favorable Biomarker to Assess Intra-Tumor Heterogeneity, in Advanced Lung Adenocarcinoma

BackgroundIntra-tumor heterogeneity (ITH) plays a vital role in drug resistance and recurrence of lung cancer. We used a mutant-allele tumor heterogeneity (MATH) algorithm to assess ITH and investigated its association with clinical and molecular features in advanced lung adenocarcinoma.MethodsTissu...

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Bibliographic Details
Main Authors: Xiaoxuan Wu, Peng Song, Lei Guo, Jianming Ying, Wenbin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
intra-tumor heterogeneity
TP53
tumor mutational burden
mutant-allele tumor heterogeneity
lung adenocarcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.888951/full

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