Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstitial Lung Disease

Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstitial Lung Disease

Idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) differ in the predominant demographics and identified genetic risk alleles of effected patients, however both diseases frequently progress to respiratory failure and death. Contrasting advanced...

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Bibliographic Details
Main Authors: Eleanor Valenzi, Tracy Tabib, Anna Papazoglou, John Sembrat, Humberto E. Trejo Bittar, Mauricio Rojas, Robert Lafyatis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
systemic sclerosis
systemic sclerosis (scleroderma)
idiopathic pulmonary fibrosis
interstitial lung disease (ILD)
single-cell RNA-sequencing (scRNA-seq)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.595811/full

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