| Summary: | Prolonged use of a standard mouse is associated with musculoskeletal symptoms. This review provides professionals with in-depth analysis of the literature regarding the evidence behind the use of alternative computer mouse designs and their ability to reduce discomfort in mouse users, in addition to the potential effect of ergonomics training and forearm supports. Multiple data bases were searched by independent researchers to identify 17 high-quality controlled trials including varieties of acceptable mouse designs (vertical, slanted, upright, roller bar, biofeedback and others). Methodological quality of these studies were assessed by independent raters utilizing the PEDro quality assessment scale and the Cochrane Risk of Bias (ROB) scale, and the results revealed that included studies were of moderate quality (5–6/10) and had some intrinsic ROB. It is concluded that there is moderate quality of evidence to support the use of alternative mouse designs to reduce discomfort, promote posture and decrease unnecessary muscle activation, especially if accompanied by appropriate ergonomic training. However, standard mouse still offers appropriate users preference levels. Hence, the consensus is that, mouse selection and purchase should be an individualized process based on individual needs and work demands and that there is no universal model that works well with everyone.
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