Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

Abstract We hypothesized that elucidating the interactome of epidermal growth factor receptor (EGFR) forms that are mutated in lung cancer, via global analysis of protein–protein interactions, phosphorylation, and systematically perturbing the ensuing network nodes, should offer a new, more systems‐...

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Détails bibliographiques
Auteurs principaux: Jiannong Li, Keiryn Bennett, Alexey Stukalov, Bin Fang, Guolin Zhang, Takeshi Yoshida, Isamu Okamoto, Jae‐Young Kim, Lanxi Song, Yun Bai, Xiaoning Qian, Bhupendra Rawal, Michael Schell, Florian Grebien, Georg Winter, Uwe Rix, Steven Eschrich, Jacques Colinge, John Koomen, Giulio Superti‐Furga, Eric B Haura
Format: Article
Langue:English
Publié: Springer Nature 2013-11-01
Collection:Molecular Systems Biology
Sujets:
epidermal growth factor receptor
interactome
lung cancer
proteomics
tyrosine kinase inhibitor
Accès en ligne:https://doi.org/10.1038/msb.2013.61

Internet

https://doi.org/10.1038/msb.2013.61

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