In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer

In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer

Abstract Background WW Domain Containing Oxidoreductase (WWOX) belongs to the unusual tumor suppressors, whose molecular function is not fully understood in bladder cancer, especially regarding interaction with Activator Protein 2 (AP-2) α/γ transcription factors. Thus, using lentiviral systems we c...

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Bibliographic Details
Main Authors: Żaneta Kałuzińska, Damian Kołat, Katarzyna Kośla, Magdalena Orzechowska, Andrzej K. Bednarek, Elżbieta Płuciennik
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Urology
Subjects:
Bladder cancer
WWOX
TFAP2A
TFAP2C
AP-2alpha
AP-2gamma
Online Access:https://doi.org/10.1186/s12894-021-00806-7

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