Effect of Qingguang'an on collagen fiber, alpha-SMA and FN in scar of filter tract after glaucoma surgery
AIM: To observe the effects on four effective components of Qingguang'an on collagen fibers, α-smooth muscle actin(α-SMA)and fibronectin(FN)in rabbits after glaucoma surgery.<p>METHODS: Apply four kinds of effective components of Qingguang'an and Qingguang'an Chinese medicine su...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2019-06-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2019/6/201906003.pdf |
| _version_ | 1818301322580983808 |
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| author | Xue-Si Huang Jun Peng Peng-Fei Jiang Yuan-Bi Li Juan Yu Qing-Hua Peng |
| author_facet | Xue-Si Huang Jun Peng Peng-Fei Jiang Yuan-Bi Li Juan Yu Qing-Hua Peng |
| author_sort | Xue-Si Huang |
| collection | DOAJ |
| description | AIM: To observe the effects on four effective components of Qingguang'an on collagen fibers, α-smooth muscle actin(α-SMA)and fibronectin(FN)in rabbits after glaucoma surgery.<p>METHODS: Apply four kinds of effective components of Qingguang'an and Qingguang'an Chinese medicine suspension to D, E, F, G, H groups after filtration surgery, and pass with group A(blank control group)and group B(model group)Compared with group C(Mitomycin C group), the effects of four effective components of Qingguang'an and Qingguang'an traditional Chinese medicine suspension on collagen fibers, α-SMA and FN in the scar tissue of glaucoma after filtration were observed.<p>RESULTS: Compare to B group, the ratio of collagen fiber area to E, F, H group, the expressions of α-SMA and the expressions of FN were different(<i>P</i><0.05). <p>CONCLUSION: Qingguang'an effective components 2, Qingguang'an effective components 3, mitomycin C and Qingguang'an suspension reduce the proliferation of myofibroblasts and fibroblasts by inhibiting the expression of collagen fibers, α-SMA and FN, and showed obvious anti-glaucoma staining scar after surgery. |
| first_indexed | 2024-12-13T05:21:10Z |
| format | Article |
| id | doaj.art-bc7a7f39b01d4487a1fdbb6d94e084e8 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-13T05:21:10Z |
| publishDate | 2019-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-bc7a7f39b01d4487a1fdbb6d94e084e82022-12-21T23:58:19ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232019-06-0119690691010.3980/j.issn.1672-5123.2019.6.03Effect of Qingguang'an on collagen fiber, alpha-SMA and FN in scar of filter tract after glaucoma surgeryXue-Si Huang0Jun Peng1Peng-Fei Jiang2Yuan-Bi Li3Juan Yu4Qing-Hua Peng5Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China; Department of Ophthalmology, the First Affiliated Hospital of Hunan College of Chinese Medicine, Zhuzhou 412000, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410208, Hunan Province, China; Hunan Provincial Key Laboratory of Otorhinolaryngology and Laryngeal Diseases, Changsha 410208, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410208, Hunan Province, China; Hunan Provincial Key Laboratory of Otorhinolaryngology and Laryngeal Diseases, Changsha 410208, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410208, Hunan Province, China; Hunan Provincial Key Laboratory of Otorhinolaryngology and Laryngeal Diseases, Changsha 410208, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410208, Hunan Province, China; Hunan Provincial Key Laboratory of Otorhinolaryngology and Laryngeal Diseases, Changsha 410208, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410208, Hunan Province, China; Hunan Provincial Key Laboratory of Otorhinolaryngology and Laryngeal Diseases, Changsha 410208, Hunan Province, ChinaAIM: To observe the effects on four effective components of Qingguang'an on collagen fibers, α-smooth muscle actin(α-SMA)and fibronectin(FN)in rabbits after glaucoma surgery.<p>METHODS: Apply four kinds of effective components of Qingguang'an and Qingguang'an Chinese medicine suspension to D, E, F, G, H groups after filtration surgery, and pass with group A(blank control group)and group B(model group)Compared with group C(Mitomycin C group), the effects of four effective components of Qingguang'an and Qingguang'an traditional Chinese medicine suspension on collagen fibers, α-SMA and FN in the scar tissue of glaucoma after filtration were observed.<p>RESULTS: Compare to B group, the ratio of collagen fiber area to E, F, H group, the expressions of α-SMA and the expressions of FN were different(<i>P</i><0.05). <p>CONCLUSION: Qingguang'an effective components 2, Qingguang'an effective components 3, mitomycin C and Qingguang'an suspension reduce the proliferation of myofibroblasts and fibroblasts by inhibiting the expression of collagen fibers, α-SMA and FN, and showed obvious anti-glaucoma staining scar after surgery.http://ies.ijo.cn/cn_publish/2019/6/201906003.pdfglaucomafiltration scarringcollagenous fibersα-SMAFN |
| spellingShingle | Xue-Si Huang Jun Peng Peng-Fei Jiang Yuan-Bi Li Juan Yu Qing-Hua Peng Effect of Qingguang'an on collagen fiber, alpha-SMA and FN in scar of filter tract after glaucoma surgery Guoji Yanke Zazhi glaucoma filtration scarring collagenous fibers α-SMA FN |
| title | Effect of Qingguang'an on collagen fiber, alpha-SMA and FN in scar of filter tract after glaucoma surgery |
| title_full | Effect of Qingguang'an on collagen fiber, alpha-SMA and FN in scar of filter tract after glaucoma surgery |
| title_fullStr | Effect of Qingguang'an on collagen fiber, alpha-SMA and FN in scar of filter tract after glaucoma surgery |
| title_full_unstemmed | Effect of Qingguang'an on collagen fiber, alpha-SMA and FN in scar of filter tract after glaucoma surgery |
| title_short | Effect of Qingguang'an on collagen fiber, alpha-SMA and FN in scar of filter tract after glaucoma surgery |
| title_sort | effect of qingguang an on collagen fiber alpha sma and fn in scar of filter tract after glaucoma surgery |
| topic | glaucoma filtration scarring collagenous fibers α-SMA FN |
| url | http://ies.ijo.cn/cn_publish/2019/6/201906003.pdf |
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