Coagulopathy biomarkers in mild to moderate CoVID-19 patients admitted in a tertiary care public hospital in eastern India
Background: The present study was undertaken to identify various prognostic biomarkers related to coagulation that may predict the outcome of mild to moderate CoVID-19 patients. Objectives: The biomarkers aPTT, PT, INR, D-Dimer, Procalcitonin, Ferritin were studied with their interdependence on each...
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Al Ameen Medical College
2021-07-01
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| Series: | Al Ameen Journal of Medical Sciences |
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| Online Access: | http://ajms.alameenmedical.org/ArticlePDFs/4%20AJMS%20V14.N3.2021%20p%20184-192.pdf |
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| author | Santasmita Pal Subhayan Lahiri Kuntal Bhattacharyya Amrita Ghosh Tapan Mukhopadhyay |
| author_facet | Santasmita Pal Subhayan Lahiri Kuntal Bhattacharyya Amrita Ghosh Tapan Mukhopadhyay |
| author_sort | Santasmita Pal |
| collection | DOAJ |
| description | Background: The present study was undertaken to identify various prognostic biomarkers related to coagulation that may predict the outcome of mild to moderate CoVID-19 patients. Objectives: The biomarkers aPTT, PT, INR, D-Dimer, Procalcitonin, Ferritin were studied with their interdependence on each other and with their severity in the CoVID-19 patients. Methods: An analytical cross-sectional study was conducted at the department of Biochemistry, and Indoor medical wards of Medical College & Hospital, Kolkata from June 2020 to December 2020 among 120 adult consecutive consenting mild to moderate patients with documented history and diagnosis of CoVID-19. Statistical analysis was done to find association of these coagulation parameters and their significant correlation to prognosticate severity of CoVID-19. Results: Highest numbers of cases were from 51-60 years age group, followed by 21-30 and 31-40 years with almost equal gender distribution; unfavourable findings were more in males in all age groups except 31-40 years, not statistically significant. Activated partial thromboplastin time (aPTT), Prothrombin time (PT), Procalcitonin (PCT), D-dimer levels were significantly higher in mild and moderate CoVID-19 cases; gender-wise difference was significant only in PCT and D-dimer levels. Ferritin levels were higher, with no significant differences in age and gender. Conclusions: Procalcitonin and D-dimer were superior biomarkers to predict severity in COVID-19 patients. These observations need further evaluation with systems approach. |
| first_indexed | 2024-12-20T13:35:26Z |
| format | Article |
| id | doaj.art-bc7c1afad59940cfb7dc6ee40fe4c7ae |
| institution | Directory Open Access Journal |
| issn | 0974-1143 0974-1143 |
| language | English |
| last_indexed | 2024-12-20T13:35:26Z |
| publishDate | 2021-07-01 |
| publisher | Al Ameen Medical College |
| record_format | Article |
| series | Al Ameen Journal of Medical Sciences |
| spelling | doaj.art-bc7c1afad59940cfb7dc6ee40fe4c7ae2022-12-21T19:38:58ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11430974-11432021-07-011403184192Coagulopathy biomarkers in mild to moderate CoVID-19 patients admitted in a tertiary care public hospital in eastern IndiaSantasmita Pal0Subhayan Lahiri1Kuntal Bhattacharyya2Amrita Ghosh3Tapan Mukhopadhyay4Department of Biochemistry, Medical College and Hospital, 88 College Street, Kolkata-700073, West Bengal, IndiaDepartment of Biochemistry, Medical College and Hospital, 88 College Street, Kolkata-700073, West Bengal, IndiaDepartment of General Medicine, Medical College and Hospital, 88 College Street, Kolkata-700073, West Bengal, IndiaDepartment of Biochemistry, Medical College and Hospital, 88 College Street, Kolkata-700073, West Bengal, IndiaDepartment of Biochemistry, Medical College and Hospital, 88 College Street, Kolkata-700073, West Bengal, IndiaBackground: The present study was undertaken to identify various prognostic biomarkers related to coagulation that may predict the outcome of mild to moderate CoVID-19 patients. Objectives: The biomarkers aPTT, PT, INR, D-Dimer, Procalcitonin, Ferritin were studied with their interdependence on each other and with their severity in the CoVID-19 patients. Methods: An analytical cross-sectional study was conducted at the department of Biochemistry, and Indoor medical wards of Medical College & Hospital, Kolkata from June 2020 to December 2020 among 120 adult consecutive consenting mild to moderate patients with documented history and diagnosis of CoVID-19. Statistical analysis was done to find association of these coagulation parameters and their significant correlation to prognosticate severity of CoVID-19. Results: Highest numbers of cases were from 51-60 years age group, followed by 21-30 and 31-40 years with almost equal gender distribution; unfavourable findings were more in males in all age groups except 31-40 years, not statistically significant. Activated partial thromboplastin time (aPTT), Prothrombin time (PT), Procalcitonin (PCT), D-dimer levels were significantly higher in mild and moderate CoVID-19 cases; gender-wise difference was significant only in PCT and D-dimer levels. Ferritin levels were higher, with no significant differences in age and gender. Conclusions: Procalcitonin and D-dimer were superior biomarkers to predict severity in COVID-19 patients. These observations need further evaluation with systems approach.http://ajms.alameenmedical.org/ArticlePDFs/4%20AJMS%20V14.N3.2021%20p%20184-192.pdfapttcovid-19d-dimerferritininrprocalcitoninpt |
| spellingShingle | Santasmita Pal Subhayan Lahiri Kuntal Bhattacharyya Amrita Ghosh Tapan Mukhopadhyay Coagulopathy biomarkers in mild to moderate CoVID-19 patients admitted in a tertiary care public hospital in eastern India Al Ameen Journal of Medical Sciences aptt covid-19 d-dimer ferritin inr procalcitonin pt |
| title | Coagulopathy biomarkers in mild to moderate CoVID-19 patients admitted in a tertiary care public hospital in eastern India |
| title_full | Coagulopathy biomarkers in mild to moderate CoVID-19 patients admitted in a tertiary care public hospital in eastern India |
| title_fullStr | Coagulopathy biomarkers in mild to moderate CoVID-19 patients admitted in a tertiary care public hospital in eastern India |
| title_full_unstemmed | Coagulopathy biomarkers in mild to moderate CoVID-19 patients admitted in a tertiary care public hospital in eastern India |
| title_short | Coagulopathy biomarkers in mild to moderate CoVID-19 patients admitted in a tertiary care public hospital in eastern India |
| title_sort | coagulopathy biomarkers in mild to moderate covid 19 patients admitted in a tertiary care public hospital in eastern india |
| topic | aptt covid-19 d-dimer ferritin inr procalcitonin pt |
| url | http://ajms.alameenmedical.org/ArticlePDFs/4%20AJMS%20V14.N3.2021%20p%20184-192.pdf |
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