Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata
Two new pentacyclic triterpene saponins, named akebiaoside K (1) and akebiaoside N (2), were isolated from the leaves of Akebia trifoliata, together with five known triterpenoids 3–7. They were all isolated from the leaves of A. trifoliata for the first time. Their structures were established by spe...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2016-07-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/21/7/962 |
| _version_ | 1818148614080299008 |
|---|---|
| author | Qiao-Lin Xu Jing Wang Li-Mei Dong Qiang Zhang Bi Luo Yong-Xia Jia Hong-Feng Wang Jian-Wen Tan |
| author_facet | Qiao-Lin Xu Jing Wang Li-Mei Dong Qiang Zhang Bi Luo Yong-Xia Jia Hong-Feng Wang Jian-Wen Tan |
| author_sort | Qiao-Lin Xu |
| collection | DOAJ |
| description | Two new pentacyclic triterpene saponins, named akebiaoside K (1) and akebiaoside N (2), were isolated from the leaves of Akebia trifoliata, together with five known triterpenoids 3–7. They were all isolated from the leaves of A. trifoliata for the first time. Their structures were established by spectral and chemical means. Triterpenes 5 and 7 were found to show moderate in vitro cytotoxicity against human tumor A549, HeLa and HepG2 cell lines, with IC50 values ranging from 0.023 to 0.038 mM. Triterpenes 5–7 were further revealed to show significant in vitro α-glucosidase inhibitory activity with IC50 values from 0.040 to 0.220 mM, making them more potent than the reference compound acarbose (IC50 0.409 mM). Meanwhile, no obvious inhibitory effects were observed for the isolated triterpene saponins 1–4 in both bioactivity assays. |
| first_indexed | 2024-12-11T12:53:56Z |
| format | Article |
| id | doaj.art-bc7d62942ca04d3c85f95c210e60afb2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T12:53:56Z |
| publishDate | 2016-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bc7d62942ca04d3c85f95c210e60afb22022-12-22T01:06:37ZengMDPI AGMolecules1420-30492016-07-0121796210.3390/molecules21070962molecules21070962Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliataQiao-Lin Xu0Jing Wang1Li-Mei Dong2Qiang Zhang3Bi Luo4Yong-Xia Jia5Hong-Feng Wang6Jian-Wen Tan7Guangdong Provincial Key Laboratory of Bio-Control for Forest Diseases and Pests, Guangdong Academy of Forestry, Guangzhou 510520, ChinaKey Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, ChinaKey Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, ChinaGuangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, ChinaGuangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, ChinaKey Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, ChinaGuangdong Provincial Key Laboratory of Bio-Control for Forest Diseases and Pests, Guangdong Academy of Forestry, Guangzhou 510520, ChinaKey Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, ChinaTwo new pentacyclic triterpene saponins, named akebiaoside K (1) and akebiaoside N (2), were isolated from the leaves of Akebia trifoliata, together with five known triterpenoids 3–7. They were all isolated from the leaves of A. trifoliata for the first time. Their structures were established by spectral and chemical means. Triterpenes 5 and 7 were found to show moderate in vitro cytotoxicity against human tumor A549, HeLa and HepG2 cell lines, with IC50 values ranging from 0.023 to 0.038 mM. Triterpenes 5–7 were further revealed to show significant in vitro α-glucosidase inhibitory activity with IC50 values from 0.040 to 0.220 mM, making them more potent than the reference compound acarbose (IC50 0.409 mM). Meanwhile, no obvious inhibitory effects were observed for the isolated triterpene saponins 1–4 in both bioactivity assays.http://www.mdpi.com/1420-3049/21/7/962Akebia trifoliatatriterpene saponinsα-glucosidase inhibitorcytotoxicity |
| spellingShingle | Qiao-Lin Xu Jing Wang Li-Mei Dong Qiang Zhang Bi Luo Yong-Xia Jia Hong-Feng Wang Jian-Wen Tan Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata Molecules Akebia trifoliata triterpene saponins α-glucosidase inhibitor cytotoxicity |
| title | Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata |
| title_full | Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata |
| title_fullStr | Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata |
| title_full_unstemmed | Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata |
| title_short | Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata |
| title_sort | two new pentacyclic triterpene saponins from the leaves of akebia trifoliata |
| topic | Akebia trifoliata triterpene saponins α-glucosidase inhibitor cytotoxicity |
| url | http://www.mdpi.com/1420-3049/21/7/962 |
| work_keys_str_mv | AT qiaolinxu twonewpentacyclictriterpenesaponinsfromtheleavesofakebiatrifoliata AT jingwang twonewpentacyclictriterpenesaponinsfromtheleavesofakebiatrifoliata AT limeidong twonewpentacyclictriterpenesaponinsfromtheleavesofakebiatrifoliata AT qiangzhang twonewpentacyclictriterpenesaponinsfromtheleavesofakebiatrifoliata AT biluo twonewpentacyclictriterpenesaponinsfromtheleavesofakebiatrifoliata AT yongxiajia twonewpentacyclictriterpenesaponinsfromtheleavesofakebiatrifoliata AT hongfengwang twonewpentacyclictriterpenesaponinsfromtheleavesofakebiatrifoliata AT jianwentan twonewpentacyclictriterpenesaponinsfromtheleavesofakebiatrifoliata |