The Causes and Risk Factors in Patients with Kernicterus Referred to the Clinic of Pediatric Neurology during the Years 2011 to 2016
Background: Neonatal jaundice has potentially severe side effects such as kernicterus. Prevention of kernicterus and hyperbilirubinemia is based on finding neonates with risk factors and starting treatment as soon as possible. Therefore, this study aimed to determine some causes and risk factors of...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2018-08-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/10118 |
| _version_ | 1797762281097920512 |
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| author | Jafar Nasiri Mohammadreza Ghazavi Mohammadali Pourmirzaei Abdorahim Pak |
| author_facet | Jafar Nasiri Mohammadreza Ghazavi Mohammadali Pourmirzaei Abdorahim Pak |
| author_sort | Jafar Nasiri |
| collection | DOAJ |
| description | Background: Neonatal jaundice has potentially severe side effects such as kernicterus. Prevention of kernicterus and hyperbilirubinemia is based on finding neonates with risk factors and starting treatment as soon as possible. Therefore, this study aimed to determine some causes and risk factors of kernicterus.
Methods: This was a retrospective descriptive study on patients referred to the clinic of pediatric neurology during the years 2011 to 2016. Reviewing patients' medical records and information was done. Quantitative data were reported as mean ± standard deviation and median, and qualitative data as frequency and percentage.
Findings: In this study, 19 clinical records were reviewed, with a mean age of 6.60 ± 4.29 years; of them, 78.9% were boys; 63.2% birthed term; 57.9% birth with natural vaginal delivery; and 52.6% had a positive family history of neonatal jaundice. The most common causes of hyperbilirubinemia were ABO and Rh incompatibility and glucose-6-phosphate dehydrogenase (G6PD) deficiency. 84.2% were treated with exchange transfusion and 15.8% with medical management. The mean age of the mothers when neonate born was 26.30 ± 3.98 years. The mean level of bilirubin level was 34.40 ± 10.46 mg/dl. Mean time of delay treatment was 1.10 ± 0.95 day.
Conclusion: Kernicterus in most cases can be prevented. Most common cause of kernicterus was the late diagnosis of families. To prevent kernicterus, it is necessary to implement a systematic after-birth care plan for neonates by qualified healthcare professionals. |
| first_indexed | 2024-03-12T19:25:06Z |
| format | Article |
| id | doaj.art-bc7d631355fd478883ade7552cdc74c7 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T19:25:06Z |
| publishDate | 2018-08-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-bc7d631355fd478883ade7552cdc74c72023-08-02T04:53:56ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2018-08-013648571271610.22122/jims.v36i485.101183124The Causes and Risk Factors in Patients with Kernicterus Referred to the Clinic of Pediatric Neurology during the Years 2011 to 2016Jafar Nasiri0Mohammadreza Ghazavi1Mohammadali Pourmirzaei2Abdorahim Pak3Assistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Neonatal jaundice has potentially severe side effects such as kernicterus. Prevention of kernicterus and hyperbilirubinemia is based on finding neonates with risk factors and starting treatment as soon as possible. Therefore, this study aimed to determine some causes and risk factors of kernicterus. Methods: This was a retrospective descriptive study on patients referred to the clinic of pediatric neurology during the years 2011 to 2016. Reviewing patients' medical records and information was done. Quantitative data were reported as mean ± standard deviation and median, and qualitative data as frequency and percentage. Findings: In this study, 19 clinical records were reviewed, with a mean age of 6.60 ± 4.29 years; of them, 78.9% were boys; 63.2% birthed term; 57.9% birth with natural vaginal delivery; and 52.6% had a positive family history of neonatal jaundice. The most common causes of hyperbilirubinemia were ABO and Rh incompatibility and glucose-6-phosphate dehydrogenase (G6PD) deficiency. 84.2% were treated with exchange transfusion and 15.8% with medical management. The mean age of the mothers when neonate born was 26.30 ± 3.98 years. The mean level of bilirubin level was 34.40 ± 10.46 mg/dl. Mean time of delay treatment was 1.10 ± 0.95 day. Conclusion: Kernicterus in most cases can be prevented. Most common cause of kernicterus was the late diagnosis of families. To prevent kernicterus, it is necessary to implement a systematic after-birth care plan for neonates by qualified healthcare professionals.http://jims.mui.ac.ir/index.php/jims/article/view/10118KernicterusHyperbilirubinemiaRisk factors |
| spellingShingle | Jafar Nasiri Mohammadreza Ghazavi Mohammadali Pourmirzaei Abdorahim Pak The Causes and Risk Factors in Patients with Kernicterus Referred to the Clinic of Pediatric Neurology during the Years 2011 to 2016 مجله دانشکده پزشکی اصفهان Kernicterus Hyperbilirubinemia Risk factors |
| title | The Causes and Risk Factors in Patients with Kernicterus Referred to the Clinic of Pediatric Neurology during the Years 2011 to 2016 |
| title_full | The Causes and Risk Factors in Patients with Kernicterus Referred to the Clinic of Pediatric Neurology during the Years 2011 to 2016 |
| title_fullStr | The Causes and Risk Factors in Patients with Kernicterus Referred to the Clinic of Pediatric Neurology during the Years 2011 to 2016 |
| title_full_unstemmed | The Causes and Risk Factors in Patients with Kernicterus Referred to the Clinic of Pediatric Neurology during the Years 2011 to 2016 |
| title_short | The Causes and Risk Factors in Patients with Kernicterus Referred to the Clinic of Pediatric Neurology during the Years 2011 to 2016 |
| title_sort | causes and risk factors in patients with kernicterus referred to the clinic of pediatric neurology during the years 2011 to 2016 |
| topic | Kernicterus Hyperbilirubinemia Risk factors |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/10118 |
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