Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption

Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption

In Drosophila, ~150 neurons expressing molecular clock proteins regulate circadian behavior. Sixteen of these neurons secrete the neuropeptide Pdf and have been called ‘master pacemakers’ because they are essential for circadian rhythms. A subset of Pdf+ neurons (the morning oscillator) regulates mo...

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Bibliographic Details
Main Authors: Rebecca Delventhal, Reed M O'Connor, Meghan M Pantalia, Matthew Ulgherait, Han X Kim, Maylis K Basturk, Julie C Canman, Mimi Shirasu-Hiza
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
CRISPR/Cas9
GAL4/UAS
circadian rhythm
Online Access:https://elifesciences.org/articles/48308

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