The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis
Introduction: Acute hepatitis is acute inflammation of liver elicited by a large number of causes. It sometimes spontaneously recovers, sometimes may progress to chronic hepatitis. LiverFatty Acid Binding Protein (L-FABP) is a small protein that is abundant in hepatocytes, and which binds most of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9621/24958_CE(EK)_F(RK)_PF1(P_SY)_PFA(GH)_PF2(SG_SS).pdf |
| Summary: | Introduction: Acute hepatitis is acute inflammation of liver
elicited by a large number of causes. It sometimes spontaneously
recovers, sometimes may progress to chronic hepatitis. LiverFatty Acid Binding Protein (L-FABP) is a small protein that is
abundant in hepatocytes, and which binds most of the longchain fatty acids present in the cytosol.
Aim: The present study was aimed to investigate the levels
of serum and urine L-FABP in acute hepatitis and diagnostic
value of serum and urine L-FABP levels in patients with acute
hepatitis.
Materials and Methods: The present study included a total of
85 patients. Total number of patients with acute hepatitis were
17 (five of acute hepatitis B, one of acute hepatitis A, two of
acute hepatitis C, five of autoimmune hepatitis and four of toxic
hepatitis), 19 of hepatic encephalopathy, 29 of liver cirrhosis, and
20 controls were included. Serum and urinary L-FABP levels were
analyzed by the Enzyme-Linked Immunosorbent Assay (ELISA).
Results: Serum L-FABP levels were 9110±3352.5, 9410±1355,
9715±2462 and 3672±982.5 ng/l in patients with acute
hepatitis, hepatic encephalopathy and cirrhosis and control
subjects, respectively. There were statistically significant
positive correlations between serum levels of L-FABP and
Aspartate Aminotransferases (AST), Alanine Aminotransferases
(ALT), Creatinine (Cre) and Gamma Glutamyl Transferases (GGT)
(p<0.001, p<0.001, p<0.001 and p<0.001, respectively). While
the cut-off value of serum L-FABP for all of the patients was
5183 ng/l {p<0.001 and Area Under Curve (AUC) 0.985}, the
sensitivity and specificity were 95.4% and 100%, respectively.
Positive and negative predictive values for serum L-FABP were
100% and 87%, respectively.
Conclusion: Serum and urine L-FABP may be a new diagnostic
marker for liver damage in patients with acute hepatitis. However,
our study showed that except of aminotransferases, L-FABP
should be used for diagnosis of liver damage in patients with
acute hepatitis, chronic hepatitis and also cirrhosis. |
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| ISSN: | 2249-782X 0973-709X |