The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis
Introduction: Acute hepatitis is acute inflammation of liver elicited by a large number of causes. It sometimes spontaneously recovers, sometimes may progress to chronic hepatitis. LiverFatty Acid Binding Protein (L-FABP) is a small protein that is abundant in hepatocytes, and which binds most of...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-04-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9621/24958_CE(EK)_F(RK)_PF1(P_SY)_PFA(GH)_PF2(SG_SS).pdf |
| _version_ | 1818575018087415808 |
|---|---|
| author | Ozlem Ozer Cakir Aysun Toker Huseyin Ataseven Ali Demir Hakki Polat |
| author_facet | Ozlem Ozer Cakir Aysun Toker Huseyin Ataseven Ali Demir Hakki Polat |
| author_sort | Ozlem Ozer Cakir |
| collection | DOAJ |
| description | Introduction: Acute hepatitis is acute inflammation of liver
elicited by a large number of causes. It sometimes spontaneously
recovers, sometimes may progress to chronic hepatitis. LiverFatty Acid Binding Protein (L-FABP) is a small protein that is
abundant in hepatocytes, and which binds most of the longchain fatty acids present in the cytosol.
Aim: The present study was aimed to investigate the levels
of serum and urine L-FABP in acute hepatitis and diagnostic
value of serum and urine L-FABP levels in patients with acute
hepatitis.
Materials and Methods: The present study included a total of
85 patients. Total number of patients with acute hepatitis were
17 (five of acute hepatitis B, one of acute hepatitis A, two of
acute hepatitis C, five of autoimmune hepatitis and four of toxic
hepatitis), 19 of hepatic encephalopathy, 29 of liver cirrhosis, and
20 controls were included. Serum and urinary L-FABP levels were
analyzed by the Enzyme-Linked Immunosorbent Assay (ELISA).
Results: Serum L-FABP levels were 9110±3352.5, 9410±1355,
9715±2462 and 3672±982.5 ng/l in patients with acute
hepatitis, hepatic encephalopathy and cirrhosis and control
subjects, respectively. There were statistically significant
positive correlations between serum levels of L-FABP and
Aspartate Aminotransferases (AST), Alanine Aminotransferases
(ALT), Creatinine (Cre) and Gamma Glutamyl Transferases (GGT)
(p<0.001, p<0.001, p<0.001 and p<0.001, respectively). While
the cut-off value of serum L-FABP for all of the patients was
5183 ng/l {p<0.001 and Area Under Curve (AUC) 0.985}, the
sensitivity and specificity were 95.4% and 100%, respectively.
Positive and negative predictive values for serum L-FABP were
100% and 87%, respectively.
Conclusion: Serum and urine L-FABP may be a new diagnostic
marker for liver damage in patients with acute hepatitis. However,
our study showed that except of aminotransferases, L-FABP
should be used for diagnosis of liver damage in patients with
acute hepatitis, chronic hepatitis and also cirrhosis. |
| first_indexed | 2024-12-15T00:34:20Z |
| format | Article |
| id | doaj.art-bc7e286477a940d6a42ae5f6dc5c9acc |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-15T00:34:20Z |
| publishDate | 2017-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-bc7e286477a940d6a42ae5f6dc5c9acc2022-12-21T22:41:51ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-04-01114OC17OC2110.7860/JCDR/2017/24958.9621The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute HepatitisOzlem Ozer Cakir0Aysun Toker1Huseyin Ataseven2Ali Demir3Hakki Polat4Associate Professor, Department of Gastroenterology and Hepatology, Konya Education and Research Hospital, Konya, Meram, Turkey.Associate Professor, Department of Biochemistry, Necmettin Erbakan University, Meram School of Medicine, Konya, Meram, Turkey.Professor, Department of Gastroenterology and Hepatology, Necmettin Erbakan University, Meram School of Medicine, Konya, Meram, Turkey.Professor, Department of Gastroenterology and Hepatology, Necmettin Erbakan University, Meram School of Medicine, Konya, Meram, Turkey.Professor, Department of Gastroenterology and Hepatology, Necmettin Erbakan University, Meram School of Medicine, Konya, Meram, Turkey.Introduction: Acute hepatitis is acute inflammation of liver elicited by a large number of causes. It sometimes spontaneously recovers, sometimes may progress to chronic hepatitis. LiverFatty Acid Binding Protein (L-FABP) is a small protein that is abundant in hepatocytes, and which binds most of the longchain fatty acids present in the cytosol. Aim: The present study was aimed to investigate the levels of serum and urine L-FABP in acute hepatitis and diagnostic value of serum and urine L-FABP levels in patients with acute hepatitis. Materials and Methods: The present study included a total of 85 patients. Total number of patients with acute hepatitis were 17 (five of acute hepatitis B, one of acute hepatitis A, two of acute hepatitis C, five of autoimmune hepatitis and four of toxic hepatitis), 19 of hepatic encephalopathy, 29 of liver cirrhosis, and 20 controls were included. Serum and urinary L-FABP levels were analyzed by the Enzyme-Linked Immunosorbent Assay (ELISA). Results: Serum L-FABP levels were 9110±3352.5, 9410±1355, 9715±2462 and 3672±982.5 ng/l in patients with acute hepatitis, hepatic encephalopathy and cirrhosis and control subjects, respectively. There were statistically significant positive correlations between serum levels of L-FABP and Aspartate Aminotransferases (AST), Alanine Aminotransferases (ALT), Creatinine (Cre) and Gamma Glutamyl Transferases (GGT) (p<0.001, p<0.001, p<0.001 and p<0.001, respectively). While the cut-off value of serum L-FABP for all of the patients was 5183 ng/l {p<0.001 and Area Under Curve (AUC) 0.985}, the sensitivity and specificity were 95.4% and 100%, respectively. Positive and negative predictive values for serum L-FABP were 100% and 87%, respectively. Conclusion: Serum and urine L-FABP may be a new diagnostic marker for liver damage in patients with acute hepatitis. However, our study showed that except of aminotransferases, L-FABP should be used for diagnosis of liver damage in patients with acute hepatitis, chronic hepatitis and also cirrhosis.https://jcdr.net/articles/PDF/9621/24958_CE(EK)_F(RK)_PF1(P_SY)_PFA(GH)_PF2(SG_SS).pdfcirrhosishepatic encephalopathysteatohepatitis |
| spellingShingle | Ozlem Ozer Cakir Aysun Toker Huseyin Ataseven Ali Demir Hakki Polat The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis Journal of Clinical and Diagnostic Research cirrhosis hepatic encephalopathy steatohepatitis |
| title | The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis |
| title_full | The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis |
| title_fullStr | The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis |
| title_full_unstemmed | The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis |
| title_short | The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis |
| title_sort | importance of liver fatty acid binding protein in diagnosis of liver damage in patients with acute hepatitis |
| topic | cirrhosis hepatic encephalopathy steatohepatitis |
| url | https://jcdr.net/articles/PDF/9621/24958_CE(EK)_F(RK)_PF1(P_SY)_PFA(GH)_PF2(SG_SS).pdf |
| work_keys_str_mv | AT ozlemozercakir theimportanceofliverfattyacidbindingproteinindiagnosisofliverdamageinpatientswithacutehepatitis AT aysuntoker theimportanceofliverfattyacidbindingproteinindiagnosisofliverdamageinpatientswithacutehepatitis AT huseyinataseven theimportanceofliverfattyacidbindingproteinindiagnosisofliverdamageinpatientswithacutehepatitis AT alidemir theimportanceofliverfattyacidbindingproteinindiagnosisofliverdamageinpatientswithacutehepatitis AT hakkipolat theimportanceofliverfattyacidbindingproteinindiagnosisofliverdamageinpatientswithacutehepatitis AT ozlemozercakir importanceofliverfattyacidbindingproteinindiagnosisofliverdamageinpatientswithacutehepatitis AT aysuntoker importanceofliverfattyacidbindingproteinindiagnosisofliverdamageinpatientswithacutehepatitis AT huseyinataseven importanceofliverfattyacidbindingproteinindiagnosisofliverdamageinpatientswithacutehepatitis AT alidemir importanceofliverfattyacidbindingproteinindiagnosisofliverdamageinpatientswithacutehepatitis AT hakkipolat importanceofliverfattyacidbindingproteinindiagnosisofliverdamageinpatientswithacutehepatitis |