Similar neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats
Background. In order to expand the hydro-mineral base of Truskavets’ spa by diluting brine (130 g/L), two new sulphate-chloride sodium-magnesium mineral waters "Myroslava" (5 g/L) and "Khrystyna" (10 g/L) were created. This report is the first in a series of experimental studies...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2021-06-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/36882 |
| _version_ | 1818249692905996288 |
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| author | Myroslava Hrytsak Daria Popovych Nataliya Badiuk Ivanna Hrytsan Walery Zukow |
| author_facet | Myroslava Hrytsak Daria Popovych Nataliya Badiuk Ivanna Hrytsan Walery Zukow |
| author_sort | Myroslava Hrytsak |
| collection | DOAJ |
| description | Background. In order to expand the hydro-mineral base of Truskavets’ spa by diluting brine (130 g/L), two new sulphate-chloride sodium-magnesium mineral waters "Myroslava" (5 g/L) and "Khrystyna" (10 g/L) were created. This report is the first in a series of experimental studies of their physiological activity in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 220-300 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the control group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The day after the completion of the drinking course in all rats assessed the state of autonomous regulation by parameters of the HRV. The plasma levels of the hormones of adaptation were determined: corticosterone, triiodothyronine and testosterone (by the ELISA); as well as electrolytes, nitric metabolites, lipid peroxidation products and antioxidant enzymes as well as cholesterol, glucose, amylase and middle mass molecules. Most of the listed parameters of metabolism as well as 17-ketosteroids were determined in daily urine. In the adrenal glands the thickness of glomerular, fascicular, reticular and medullar zones was measured. Results. To identify exactly those parameters, the set of which three groups of animals differ significantly from each other, the information field of the registered parameters was subjected to discriminant analysis. The program included in the model 6 endocrine and 11 metabolic parameters, as well as glomerular filtration. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have similar neuroendocrine and metabolic effects on healthy old female rats significantly different from daily water.
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| first_indexed | 2024-12-12T15:40:32Z |
| format | Article |
| id | doaj.art-bc80a2c7e6784e18b21fea366aa74d89 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-12T15:40:32Z |
| publishDate | 2021-06-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-bc80a2c7e6784e18b21fea366aa74d892022-12-22T00:19:55ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062021-06-0111610.12775/JEHS.2021.11.06.035Similar neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female ratsMyroslava Hrytsak0Daria Popovych1Nataliya Badiuk2Ivanna Hrytsan3Walery Zukow4SE Ukrainian Research Institute for Medicine of Transport, Odesa; Scientific group of Balneology of Hotel&Spa Complex "Karpaty", Truskavets’, Ukraine IY Horbachevs’kyi National Medical University, Ternopil’SE Ukrainian Research Institute for Medicine of Transport, Odesa; International Medical University, OdesaSE Ukrainian Research Institute for Medicine of Transport, Odesa; International Medical University, OdesaNicolaus Copernicus University in Torun, TorunBackground. In order to expand the hydro-mineral base of Truskavets’ spa by diluting brine (130 g/L), two new sulphate-chloride sodium-magnesium mineral waters "Myroslava" (5 g/L) and "Khrystyna" (10 g/L) were created. This report is the first in a series of experimental studies of their physiological activity in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 220-300 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the control group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The day after the completion of the drinking course in all rats assessed the state of autonomous regulation by parameters of the HRV. The plasma levels of the hormones of adaptation were determined: corticosterone, triiodothyronine and testosterone (by the ELISA); as well as electrolytes, nitric metabolites, lipid peroxidation products and antioxidant enzymes as well as cholesterol, glucose, amylase and middle mass molecules. Most of the listed parameters of metabolism as well as 17-ketosteroids were determined in daily urine. In the adrenal glands the thickness of glomerular, fascicular, reticular and medullar zones was measured. Results. To identify exactly those parameters, the set of which three groups of animals differ significantly from each other, the information field of the registered parameters was subjected to discriminant analysis. The program included in the model 6 endocrine and 11 metabolic parameters, as well as glomerular filtration. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have similar neuroendocrine and metabolic effects on healthy old female rats significantly different from daily water. https://apcz.umk.pl/JEHS/article/view/36882sulfate-chloride sodium-magnesium drinking mineral watersTruskavets’ spaneuroendocrine and metabolic parametersfemale rats |
| spellingShingle | Myroslava Hrytsak Daria Popovych Nataliya Badiuk Ivanna Hrytsan Walery Zukow Similar neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats Journal of Education, Health and Sport sulfate-chloride sodium-magnesium drinking mineral waters Truskavets’ spa neuroendocrine and metabolic parameters female rats |
| title | Similar neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats |
| title_full | Similar neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats |
| title_fullStr | Similar neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats |
| title_full_unstemmed | Similar neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats |
| title_short | Similar neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats |
| title_sort | similar neuroendocrine and metabolic effects of sulfate chloride sodium magnesium mineral waters myroslava and khrystyna of truskavets spa in healthy female rats |
| topic | sulfate-chloride sodium-magnesium drinking mineral waters Truskavets’ spa neuroendocrine and metabolic parameters female rats |
| url | https://apcz.umk.pl/JEHS/article/view/36882 |
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