Feedback Regulation of Syk by Protein Kinase C in Human Platelets

Feedback Regulation of Syk by Protein Kinase C in Human Platelets

The spleen tyrosine kinase (Syk) is essential for immunoreceptor tyrosine-based activation motif (ITAM)-dependent platelet activation, and it is stimulated by Src-family kinase (SFK)-/Syk-mediated phosphorylation of Y352 (interdomain-B) and Y525/526 (kinase domain). Additional sites for Syk phosphor...

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Bibliographic Details
Main Authors: Stephanie Makhoul, Stephanie Dorschel, Stepan Gambaryan, Ulrich Walter, Kerstin Jurk
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:International Journal of Molecular Sciences
Subjects:
spleen tyrosine kinase (syk)
protein kinase c
cyclic adenosine monophosphate (camp)
platelets
glycoprotein vi
glycoprotein ibα
Online Access:https://www.mdpi.com/1422-0067/21/1/176

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