Brain MR Spectroscopy in Autism Spectrum Disorder- the GABA excitatory/inhibitory imbalance theory revisited
Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-06-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00365/full |
| _version_ | 1818403689394601984 |
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| author | Maiken Kirkegaard Brix Maiken Kirkegaard Brix Lars eErsland Lars eErsland Kenneth eHugdahl Kenneth eHugdahl Kenneth eHugdahl Kenneth eHugdahl Renate eGrüner Renate eGrüner Renate eGrüner Maj-Britt ePosserud Åsa eHammar Alexander R Craven Alexander R Craven Ralph eNoeske C. John eEvans Hanne Bjørg eWalker Tore eMidtvedt Mona K Beyer Mona K Beyer |
| author_facet | Maiken Kirkegaard Brix Maiken Kirkegaard Brix Lars eErsland Lars eErsland Kenneth eHugdahl Kenneth eHugdahl Kenneth eHugdahl Kenneth eHugdahl Renate eGrüner Renate eGrüner Renate eGrüner Maj-Britt ePosserud Åsa eHammar Alexander R Craven Alexander R Craven Ralph eNoeske C. John eEvans Hanne Bjørg eWalker Tore eMidtvedt Mona K Beyer Mona K Beyer |
| author_sort | Maiken Kirkegaard Brix |
| collection | DOAJ |
| description | Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels. |
| first_indexed | 2024-12-14T08:28:15Z |
| format | Article |
| id | doaj.art-bc82946ca7f74a5f8a45a228e165a44c |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-14T08:28:15Z |
| publishDate | 2015-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-bc82946ca7f74a5f8a45a228e165a44c2022-12-21T23:09:35ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612015-06-01910.3389/fnhum.2015.00365147946Brain MR Spectroscopy in Autism Spectrum Disorder- the GABA excitatory/inhibitory imbalance theory revisitedMaiken Kirkegaard Brix0Maiken Kirkegaard Brix1Lars eErsland2Lars eErsland3Kenneth eHugdahl4Kenneth eHugdahl5Kenneth eHugdahl6Kenneth eHugdahl7Renate eGrüner8Renate eGrüner9Renate eGrüner10Maj-Britt ePosserud11Åsa eHammar12Alexander R Craven13Alexander R Craven14Ralph eNoeske15C. John eEvans16Hanne Bjørg eWalker17Tore eMidtvedt18Mona K Beyer19Mona K Beyer20Department of Radiology, Haukeland University Hospital, University of Bergen, Haukeland University Hospital, University of BergenDepartment of Radiology, Haukeland University Hospital, University of BergenUniversity of BergenHaukeland University HospitalDepartment of Radiology, Haukeland University Hospital, University of BergenUniversity of BergenHaukeland University HospitalUniversity of BergenUniversity of BergenUniversity of BergenGE HealthcareCardiff University / Prifysgol CaerdyddUniversity of OsloKarolinska InstituteOslo University HospitalOslo and Akershus University College of Applied SciencesMagnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00365/fullGABAASDMRSASSQMEGA-PRESS |
| spellingShingle | Maiken Kirkegaard Brix Maiken Kirkegaard Brix Lars eErsland Lars eErsland Kenneth eHugdahl Kenneth eHugdahl Kenneth eHugdahl Kenneth eHugdahl Renate eGrüner Renate eGrüner Renate eGrüner Maj-Britt ePosserud Åsa eHammar Alexander R Craven Alexander R Craven Ralph eNoeske C. John eEvans Hanne Bjørg eWalker Tore eMidtvedt Mona K Beyer Mona K Beyer Brain MR Spectroscopy in Autism Spectrum Disorder- the GABA excitatory/inhibitory imbalance theory revisited Frontiers in Human Neuroscience GABA ASD MRS ASSQ MEGA-PRESS |
| title | Brain MR Spectroscopy in Autism Spectrum Disorder- the GABA excitatory/inhibitory imbalance theory revisited |
| title_full | Brain MR Spectroscopy in Autism Spectrum Disorder- the GABA excitatory/inhibitory imbalance theory revisited |
| title_fullStr | Brain MR Spectroscopy in Autism Spectrum Disorder- the GABA excitatory/inhibitory imbalance theory revisited |
| title_full_unstemmed | Brain MR Spectroscopy in Autism Spectrum Disorder- the GABA excitatory/inhibitory imbalance theory revisited |
| title_short | Brain MR Spectroscopy in Autism Spectrum Disorder- the GABA excitatory/inhibitory imbalance theory revisited |
| title_sort | brain mr spectroscopy in autism spectrum disorder the gaba excitatory inhibitory imbalance theory revisited |
| topic | GABA ASD MRS ASSQ MEGA-PRESS |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00365/full |
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