Chemotherapeutic Drugs Induce Different Gut Microbiota Disorder Pattern and NOD/RIP2/NF-κB Signaling Pathway Activation That Lead to Different Degrees of Intestinal Injury

Chemotherapeutic Drugs Induce Different Gut Microbiota Disorder Pattern and NOD/RIP2/NF-κB Signaling Pathway Activation That Lead to Different Degrees of Intestinal Injury

ABSTRACT 5-Fluorouracil (5-FU), irinotecan (CPT-11), oxaliplatin (L-OHP), and calcium folinate (CF) are widely used chemotherapeutic drugs to treat colorectal cancer. However, chemotherapeutic use is often accompanied by intestinal inflammation and gut microbiota disorder. Changes in gut microbiota...

Full description

Bibliographic Details
Main Authors: Bin Huang, Mengxuan Gui, Zhuona Ni, Yanbin He, Jinyan Zhao, Jun Peng, Jiumao Lin
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
colorectal cancer
chemotherapeutic drugs
intestinal injury
5-fluorouracil
irinotecan
oxaliplatin
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01677-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01677-22

Similar Items