Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
A spectrophotometric method based on the formation of ion-pair complex between haloperidol and eriochrome black T (EBT) at pH 1.85 has been described. The formed complex was extracted quantitatively into chloroform and measured at 510 nm. Infra red (IR) studies were performed to confirm the formatio...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2012-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000200028&lng=en&tlng=en |
| _version_ | 1818624664046403584 |
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| author | Nafisur Rahman Asma Khatoon Habibur Rahman |
| author_facet | Nafisur Rahman Asma Khatoon Habibur Rahman |
| author_sort | Nafisur Rahman |
| collection | DOAJ |
| description | A spectrophotometric method based on the formation of ion-pair complex between haloperidol and eriochrome black T (EBT) at pH 1.85 has been described. The formed complex was extracted quantitatively into chloroform and measured at 510 nm. Infra red (IR) studies were performed to confirm the formation of ion-pair complex. Beer's law was obeyed in the concentration range of 2.0-9.0 µg mL-1 with molar absorptivity of 2.67 × 10(4) L mol-1 cm-1. The detection limit was found to be 0.18 µg mL-1. Statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision. |
| first_indexed | 2024-12-16T19:00:33Z |
| format | Article |
| id | doaj.art-bc85180deebb455ba76b79ea04b463dc |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-16T19:00:33Z |
| publishDate | 2012-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-bc85180deebb455ba76b79ea04b463dc2022-12-21T22:20:25ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642012-01-0135239239710.1590/S0100-40422012000200028S0100-40422012000200028Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparationsNafisur Rahman0Asma Khatoon1Habibur Rahman2Aligarh Muslim UniversityAligarh Muslim UniversityAligarh Muslim UniversityA spectrophotometric method based on the formation of ion-pair complex between haloperidol and eriochrome black T (EBT) at pH 1.85 has been described. The formed complex was extracted quantitatively into chloroform and measured at 510 nm. Infra red (IR) studies were performed to confirm the formation of ion-pair complex. Beer's law was obeyed in the concentration range of 2.0-9.0 µg mL-1 with molar absorptivity of 2.67 × 10(4) L mol-1 cm-1. The detection limit was found to be 0.18 µg mL-1. Statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000200028&lng=en&tlng=enhaloperidolion-pair complexspectrophotometry |
| spellingShingle | Nafisur Rahman Asma Khatoon Habibur Rahman Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations Química Nova haloperidol ion-pair complex spectrophotometry |
| title | Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations |
| title_full | Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations |
| title_fullStr | Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations |
| title_full_unstemmed | Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations |
| title_short | Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations |
| title_sort | studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations |
| topic | haloperidol ion-pair complex spectrophotometry |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000200028&lng=en&tlng=en |
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