A Novel Ratiometric Fluorescent Probe for Mercury (II) ions and Application in Bio-imaging
Since the accumulation of mercury (II) ions in the environment and ecosystem causes serious problems to environment and disease, the recognition of Hg<sup>2+</sup> ions and its bio-imaging is of high importance. In sight of the advantages of fluorescence probes, a new probe (<b>PMH...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-06-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/12/2268 |
| Summary: | Since the accumulation of mercury (II) ions in the environment and ecosystem causes serious problems to environment and disease, the recognition of Hg<sup>2+</sup> ions and its bio-imaging is of high importance. In sight of the advantages of fluorescence probes, a new probe (<b>PMH</b>) was facilely synthesized by incorporating phenylimidazole fluorophore and 3-methyl-2- benzothiazolinone hydrazone hydrochloride monohydrate. The <b>PMH</b> probe exhibited a ratiometric response for Hg<sup>2+</sup> ions with fluorescence intensity increasing at 520 nm and decreasing at 445 nm simultaneously. The <b>PMH</b> probe interacted with Hg<sup>2+</sup> ions in seconds with high optical stability and showed good selectivity over other metal ions. In addition, the probe has excellent biocompatibility and imaging performance in cells and zebrafish. |
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| ISSN: | 1420-3049 |