A Novel Ratiometric Fluorescent Probe for Mercury (II) ions and Application in Bio-imaging
Since the accumulation of mercury (II) ions in the environment and ecosystem causes serious problems to environment and disease, the recognition of Hg<sup>2+</sup> ions and its bio-imaging is of high importance. In sight of the advantages of fluorescence probes, a new probe (<b>PMH...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/12/2268 |
| _version_ | 1818618684942319616 |
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| author | Qianmiao Gao Yang Jiao Cheng He Chunying Duan |
| author_facet | Qianmiao Gao Yang Jiao Cheng He Chunying Duan |
| author_sort | Qianmiao Gao |
| collection | DOAJ |
| description | Since the accumulation of mercury (II) ions in the environment and ecosystem causes serious problems to environment and disease, the recognition of Hg<sup>2+</sup> ions and its bio-imaging is of high importance. In sight of the advantages of fluorescence probes, a new probe (<b>PMH</b>) was facilely synthesized by incorporating phenylimidazole fluorophore and 3-methyl-2- benzothiazolinone hydrazone hydrochloride monohydrate. The <b>PMH</b> probe exhibited a ratiometric response for Hg<sup>2+</sup> ions with fluorescence intensity increasing at 520 nm and decreasing at 445 nm simultaneously. The <b>PMH</b> probe interacted with Hg<sup>2+</sup> ions in seconds with high optical stability and showed good selectivity over other metal ions. In addition, the probe has excellent biocompatibility and imaging performance in cells and zebrafish. |
| first_indexed | 2024-12-16T17:25:31Z |
| format | Article |
| id | doaj.art-bc8b696ac7804c8ba38ebeea75b7c6a5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-16T17:25:31Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bc8b696ac7804c8ba38ebeea75b7c6a52022-12-21T22:23:04ZengMDPI AGMolecules1420-30492019-06-012412226810.3390/molecules24122268molecules24122268A Novel Ratiometric Fluorescent Probe for Mercury (II) ions and Application in Bio-imagingQianmiao Gao0Yang Jiao1Cheng He2Chunying Duan3State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, ChinaState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, ChinaState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, ChinaState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, ChinaSince the accumulation of mercury (II) ions in the environment and ecosystem causes serious problems to environment and disease, the recognition of Hg<sup>2+</sup> ions and its bio-imaging is of high importance. In sight of the advantages of fluorescence probes, a new probe (<b>PMH</b>) was facilely synthesized by incorporating phenylimidazole fluorophore and 3-methyl-2- benzothiazolinone hydrazone hydrochloride monohydrate. The <b>PMH</b> probe exhibited a ratiometric response for Hg<sup>2+</sup> ions with fluorescence intensity increasing at 520 nm and decreasing at 445 nm simultaneously. The <b>PMH</b> probe interacted with Hg<sup>2+</sup> ions in seconds with high optical stability and showed good selectivity over other metal ions. In addition, the probe has excellent biocompatibility and imaging performance in cells and zebrafish.https://www.mdpi.com/1420-3049/24/12/2268fluorescent probeHg<sup>2+</sup> ionsphenylimidazole |
| spellingShingle | Qianmiao Gao Yang Jiao Cheng He Chunying Duan A Novel Ratiometric Fluorescent Probe for Mercury (II) ions and Application in Bio-imaging Molecules fluorescent probe Hg<sup>2+</sup> ions phenylimidazole |
| title | A Novel Ratiometric Fluorescent Probe for Mercury (II) ions and Application in Bio-imaging |
| title_full | A Novel Ratiometric Fluorescent Probe for Mercury (II) ions and Application in Bio-imaging |
| title_fullStr | A Novel Ratiometric Fluorescent Probe for Mercury (II) ions and Application in Bio-imaging |
| title_full_unstemmed | A Novel Ratiometric Fluorescent Probe for Mercury (II) ions and Application in Bio-imaging |
| title_short | A Novel Ratiometric Fluorescent Probe for Mercury (II) ions and Application in Bio-imaging |
| title_sort | novel ratiometric fluorescent probe for mercury ii ions and application in bio imaging |
| topic | fluorescent probe Hg<sup>2+</sup> ions phenylimidazole |
| url | https://www.mdpi.com/1420-3049/24/12/2268 |
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