Diagnostic value of fibrinogen to prealbumin ratio and gamma-glutamyl transpeptidase to platelet ratio in the progression of AFP-negative hepatocellular carcinoma
Abstract Background This study aimed to comprehensively assess the diagnostic value of fibrinogen to prealbumin ratio (FPR) and gamma-glutamyl transpeptidase to platelet ratio (GPR) as single markers or in combination in patients with alpha-fetoprotein-negative (AFP-negative) hepatocellular carcinom...
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | Cancer Cell International |
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| Online Access: | http://link.springer.com/article/10.1186/s12935-020-1161-y |
| _version_ | 1811327326901764096 |
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| author | Li Huang Zhuning Mo Zuojian Hu Linyan Zhang Shanzi Qin Xue Qin Shan Li |
| author_facet | Li Huang Zhuning Mo Zuojian Hu Linyan Zhang Shanzi Qin Xue Qin Shan Li |
| author_sort | Li Huang |
| collection | DOAJ |
| description | Abstract Background This study aimed to comprehensively assess the diagnostic value of fibrinogen to prealbumin ratio (FPR) and gamma-glutamyl transpeptidase to platelet ratio (GPR) as single markers or in combination in patients with alpha-fetoprotein-negative (AFP-negative) hepatocellular carcinoma (HCC). Methods A total of 199 healthy controls and 515 AFP-negative patients were enrolled in this study, including 180 HCC inpatients, 151 liver cirrhosis (LC) patients, and 184 chronic hepatitis (CH) cases. Mann–Whitney U or Kruskal–Wallis H test were used to analyze differences between groups in laboratory parameters and clinicopathological features. The diagnostic value of FPR and GPR, alone or in combination, in AFP-negative HCC (AFP-NHCC) patients was determined via a receiver operating characteristic (ROC) curve. Results The levels of FPR and GPR were gradually increased in the development of AFP-NHCC and positively correlated with the tumor size and Barcelona Clinic Liver Cancer (BCLC) stages. Moreover, GPR was associated with Edmondson–Steiner grades. After univariate logistic regression analysis, FPR and GPR remained independent predictors of adverse outcomes. The combination of FPR and GPR had a good ability to detect AFP-NHCC from the control group (area under curve [AUC] = 0.977), AFP-negative CH (AUC = 0.745), and AFP-negative LC (AUC = 0.666). FPR combined with GPR possessed a larger area (0.943, 0.971) and sensitivity (87.50%, 89.81%) than FPR or GPR alone for differentiating AFP-NHCC with tumor size < 3 cm or at the BCLC-A stage. Conclusions The pretreatment levels of FPR and GPR played vital roles in the development of AFP-NHCC, especially in patients with early or small AFP-NHCC. |
| first_indexed | 2024-04-13T15:04:39Z |
| format | Article |
| id | doaj.art-bc8b7f073e6142a48b884b4a97e9bcea |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-13T15:04:39Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-bc8b7f073e6142a48b884b4a97e9bcea2022-12-22T02:42:11ZengBMCCancer Cell International1475-28672020-03-0120111010.1186/s12935-020-1161-yDiagnostic value of fibrinogen to prealbumin ratio and gamma-glutamyl transpeptidase to platelet ratio in the progression of AFP-negative hepatocellular carcinomaLi Huang0Zhuning Mo1Zuojian Hu2Linyan Zhang3Shanzi Qin4Xue Qin5Shan Li6Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical UniversityDepartment of Blood Transfusion, The People’s Hospital of Guangxi Zhuang Autonomous RegionDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical UniversityDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical UniversityDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical UniversityDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical UniversityDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical UniversityAbstract Background This study aimed to comprehensively assess the diagnostic value of fibrinogen to prealbumin ratio (FPR) and gamma-glutamyl transpeptidase to platelet ratio (GPR) as single markers or in combination in patients with alpha-fetoprotein-negative (AFP-negative) hepatocellular carcinoma (HCC). Methods A total of 199 healthy controls and 515 AFP-negative patients were enrolled in this study, including 180 HCC inpatients, 151 liver cirrhosis (LC) patients, and 184 chronic hepatitis (CH) cases. Mann–Whitney U or Kruskal–Wallis H test were used to analyze differences between groups in laboratory parameters and clinicopathological features. The diagnostic value of FPR and GPR, alone or in combination, in AFP-negative HCC (AFP-NHCC) patients was determined via a receiver operating characteristic (ROC) curve. Results The levels of FPR and GPR were gradually increased in the development of AFP-NHCC and positively correlated with the tumor size and Barcelona Clinic Liver Cancer (BCLC) stages. Moreover, GPR was associated with Edmondson–Steiner grades. After univariate logistic regression analysis, FPR and GPR remained independent predictors of adverse outcomes. The combination of FPR and GPR had a good ability to detect AFP-NHCC from the control group (area under curve [AUC] = 0.977), AFP-negative CH (AUC = 0.745), and AFP-negative LC (AUC = 0.666). FPR combined with GPR possessed a larger area (0.943, 0.971) and sensitivity (87.50%, 89.81%) than FPR or GPR alone for differentiating AFP-NHCC with tumor size < 3 cm or at the BCLC-A stage. Conclusions The pretreatment levels of FPR and GPR played vital roles in the development of AFP-NHCC, especially in patients with early or small AFP-NHCC.http://link.springer.com/article/10.1186/s12935-020-1161-yFibrinogen to prealbumin ratioGamma-glutamyl transpeptidase to platelet ratioDiagnosticAFP-negative hepatocellular carcinoma |
| spellingShingle | Li Huang Zhuning Mo Zuojian Hu Linyan Zhang Shanzi Qin Xue Qin Shan Li Diagnostic value of fibrinogen to prealbumin ratio and gamma-glutamyl transpeptidase to platelet ratio in the progression of AFP-negative hepatocellular carcinoma Cancer Cell International Fibrinogen to prealbumin ratio Gamma-glutamyl transpeptidase to platelet ratio Diagnostic AFP-negative hepatocellular carcinoma |
| title | Diagnostic value of fibrinogen to prealbumin ratio and gamma-glutamyl transpeptidase to platelet ratio in the progression of AFP-negative hepatocellular carcinoma |
| title_full | Diagnostic value of fibrinogen to prealbumin ratio and gamma-glutamyl transpeptidase to platelet ratio in the progression of AFP-negative hepatocellular carcinoma |
| title_fullStr | Diagnostic value of fibrinogen to prealbumin ratio and gamma-glutamyl transpeptidase to platelet ratio in the progression of AFP-negative hepatocellular carcinoma |
| title_full_unstemmed | Diagnostic value of fibrinogen to prealbumin ratio and gamma-glutamyl transpeptidase to platelet ratio in the progression of AFP-negative hepatocellular carcinoma |
| title_short | Diagnostic value of fibrinogen to prealbumin ratio and gamma-glutamyl transpeptidase to platelet ratio in the progression of AFP-negative hepatocellular carcinoma |
| title_sort | diagnostic value of fibrinogen to prealbumin ratio and gamma glutamyl transpeptidase to platelet ratio in the progression of afp negative hepatocellular carcinoma |
| topic | Fibrinogen to prealbumin ratio Gamma-glutamyl transpeptidase to platelet ratio Diagnostic AFP-negative hepatocellular carcinoma |
| url | http://link.springer.com/article/10.1186/s12935-020-1161-y |
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